1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Resolvin D1

Resolvin D1  (Synonyms: RvD1)

目录号: HY-125527 纯度: ≥99.0%
COA 产品使用指南

Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质,衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移,减少巨噬细胞中 TNF-α 介导的炎症,并增强巨噬细胞对凋亡细胞的吞噬作用。

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Resolvin D1 Chemical Structure

Resolvin D1 Chemical Structure

CAS No. : 872993-05-0

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25 μg (265.6 µM * 250 μL in Ethanol) ¥8500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Resolvin D1 (RvD1) (1-100 nM;15 分钟) 在原代人巨噬细胞中诱导剂量依赖性短期功能变化。RvD1 触发细胞内 Ca2+ 释放,阻断趋化性迁移,并刺激微生物颗粒的吞噬作用,在 10 nM时效率最高[1]
Resolvin D1 (0-500 nM;72 小时) 在 RAW264.7 巨噬细胞中显示出不同浓度的 RvD1 对 LPS 诱导的 TRAP 和组织蛋白酶 K 表达的强烈抑制作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Resolvin D1 (RvD1) (100-1000 ng;腹腔注射;第 10 天每天) 改善关节炎小鼠的 RA (类风湿性关节炎) 临床终点[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))[3]
Dosage: 100, 500, and 1000 ng (or 1000 ng, daily on days 4-10)
Administration: i.p. injection; daily on days 10
Result: Exhibit a reduced arthritic score.
分子量

376.49

Formula

C22H32O5

CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: 99.60%

参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Resolvin D1
目录号:
HY-125527
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