Resolvin E1  (Synonyms: RvE1)

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production^[1][2].

Resolvin E1 (0.1-100 nM) 浓度依赖性抑制 TNF-α 诱导的 NF-κB 激活，在 ChemR23 转染的细胞中的 EC₅₀ 为 ~1.0 nM。Resolvin E1 (100 nM) 增加外周血单核细胞和 HEK-ChemR23 细胞中细胞外信号调节激酶 (ERK) 丝裂原活化蛋白 (MAP) 激酶的磷酸化^[2]。Resolvin E1 特异性地与中性粒细胞上的 LTB 受体 BLT1 和单核细胞上的 ChemR23 相互作用，以在炎症期间调节白细胞₄。Resolvin E1 还刺激局部细胞因子的摄取和清除^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin E1 (每只小鼠 1.0 μg；50 μg/kg；腹腔注射；第-8、-1 和 0 天) 保护小鼠免受 TNBS (2，4，6-三硝基苯磺酸) 结肠炎^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

350.45

C₂₀H₃₀O₅

552830-51-0

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6.  [Content Brief]

  [2]. Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447(7146):869-74.  [Content Brief]

  [3]. Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179(10):7021-9.  [Content Brief]