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  4. RX 336M

RX 336M 是一种二氢可待因酮类似物。RX 336M 可诱导出一系列行为，表现为行为兴奋、前爪快速运动、过度梳理毛发以及全身 “湿狗” 样抖动 (WDS，头部和躯干快速扭动，前爪离地)。RX 336M 可用于神经系统疾病的研究。

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RX 336M

RX 336M Chemical Structure

CAS No. : 6701-66-2

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RX 336M 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease[1][2].

体内研究
(In Vivo)

RX 336M (1.5-12 mg/kg，腹腔注射，单剂量) 可在大鼠中诱导出与剂量、年龄和性别相关的 “湿狗样” 颤抖和过度理毛行为[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (weight ranges: 80-90 g, 120-140 g, 190-210 g, 280-300 g)[1]
Dosage: 1.5, 3, 6, 12 mg/kg
Administration: i.p. for a single dose
Result: Induced grooming behavior that primarily involved face washing and preening of the flanks with the mouth or forepaws, with very little hindpaw scratching.
Caused a sequential behavioral pattern in rats: shaking first, followed by face washing, then grooming of the flanks, and repetition of this sequence.
Led to a decrease in the correlation between the number of "wet-dog" shakes (WDS) and the percentage of maximum possible grooming episodes (%MGE).
Showed improved correlation between WDS and %MGE in rats weighing 190-210 g and 280-300 g.
Increased the number of WDS but decreased the correlation between WDS and grooming when the dose was doubled to 12 mg/kg in large rats.
Resulted in a decline in %MGE but an improvement in the correlation between shaking and grooming.
Animal Model: Male and female Long-Evans rats of different ages (21 days, 30 days, 39 days, and 48 days old)[2]
Dosage: 6 mg/kg
Administration: i.p. for a single dose
Result: Induced more significant excessive grooming in younger rats than in older ones, with gender differences.
Caused age- and sex-related differences in the frequency of "wet-dog" shakes (WDS).
Had no significant effect on the activity levels (rearing and locomotion) of rats, while female rats generally had higher activity levels than males.
Animal Model: 39-day-old female Long-Evans rats received daily subcutaneous injections of testosterone benzoate (1 mg/kg/day) for 8 consecutive days starting from 32 days old[2]
Dosage: 6 mg/kg
Administration: i.p. for a single dose
Result: Enhanced the responses of female rats to excessive grooming and "wet-dog" shakes.
Had no significant behavioral effects in 39-day-old female rats pretreated with oil vehicle.
分子量

379.49

Formula

C24H29NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RX 336M 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 336M6701-66-2Drug DerivativeDrug derivativedihydrocodeinonequasi-morphine withdrawal syndromeInhibitorinhibitorinhibit

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产品名称：
RX 336M
目录号：
HY-122125
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