2. Anti-infection
  3. Fungal
  4. S-F24

S-F24 是一种具有良好广谱性的抗真菌剂(fungal)。S-F24 抑制 CYP3A4 的 IC50 为 0.4 μM。S-F24 具有安全性，高选择性，低溶血作用和低诱导耐药性的倾向。S-F24 可用于真菌感染的研究。

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S-F24 Chemical Structure

S-F24 Chemical Structure

CAS No. : 2946669-78-7

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S-F24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections[1].

体外研究
(In Vitro)

S-F24 (10-30 μM，48 h) 对哺乳动物细胞的毒性较弱[1]。
S-F24 (0.002 μg/mL，20 passages) 对抗 C. albicans SC5314 的 MIC80 值增加 8 倍[1]。
S-F24 (0.004 μg/mL，16 h) 在 C. albicans SC5314 中抑制麦角甾醇合成达 92.03%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S-F24 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HUVEC, MCF-10A, 16HBE, LO2
Concentration: 0.4 μM, 10-30 μM
Incubation Time: 48 h
Result: Displayed weak cytotoxicity with IC50 values ranging from 13.97 to 29.22 μM.
Inhibited CYP3A4 with an IC50 value of 0.4 μM.
体内研究
(In Vivo)

S-F24 (1，5 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中广泛应用于处理 C. albicans SC5314， A. fumigatus CGMCC3.7795，和 耐药 C. albicans 24D 的真菌侵袭性感染[1]。
S-F24 (0.5，1 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中抑制皮肤感染 C. albicans SC5314 非常有效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse models infected systemically with C. albicans SC5314, or A. fumigatus CGMCC3.7795, or multi-resistant C. albicans 24D[1]
Dosage: 1, 5 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Increased the median survival time (MST) to 6 days at 1.0 mg/kg/day in C. albicans SC5314 challenge.
Increased the MST in a dose-dependent manner significantly in fumigatus CGMCC3.7795 challenge.
Increased the MST to 12 days at 1.0 mg/kg/day in multi-resistant C. albicans 24D challenge.
Animal Model: C. albicans[1].
Dosage: 0.5, 1 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced the fungal burden significantly and showed better therapeutic effects than the Luli (HY-14283) (1 mg/kg) group.
Inhibited fungi almost completely in the group at 1.0 mg/kg.
分子量

545.42

Formula

C25H27BrF2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S-F24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-F242946669-78-7FungalHUVECMCF-10A16HBELO2selectivityinvasive and superficial fungal infection in ICR micefungal infectionInhibitorinhibitorinhibit

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HY-149844
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