2. Anti-infection
  3. Fungal
  4. S-F24

S-F24 是一种具有良好广谱性的抗真菌剂(fungal)。S-F24 抑制 CYP3A4 的 IC50 为 0.4 μM。S-F24 具有安全性，高选择性，低溶血作用和低诱导耐药性的倾向。S-F24 可用于真菌感染的研究。

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S-F24

S-F24 Chemical Structure

CAS No. : 2946669-78-7

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S-F24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
16HBE14o- IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human 16HBE14o- cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
HUVEC IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
L02 IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
MCF-10A IC50
13.97 μM
Compound: S-F24
Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell viability measured after 48 hrs by MTT assay
[PMID: 37218609]
体外研究
(In Vitro)

S-F24 (10-30 μM，48 h) 对哺乳动物细胞的毒性较弱[1]。
S-F24 (0.002 μg/mL，20 passages) 对抗 C. albicans SC5314 的 MIC80 值增加 8 倍[1]。
S-F24 (0.004 μg/mL，16 h) 在 C. albicans SC5314 中抑制麦角甾醇合成达 92.03%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S-F24 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HUVEC, MCF-10A, 16HBE, LO2
Concentration: 0.4 μM, 10-30 μM
Incubation Time: 48 h
Result: Displayed weak cytotoxicity with IC50 values ranging from 13.97 to 29.22 μM.
Inhibited CYP3A4 with an IC50 value of 0.4 μM.
体内研究
(In Vivo)

S-F24 (1，5 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中广泛应用于处理 C. albicans SC5314， A. fumigatus CGMCC3.7795，和 耐药 C. albicans 24D 的真菌侵袭性感染[1]。
S-F24 (0.5，1 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中抑制皮肤感染 C. albicans SC5314 非常有效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse models infected systemically with C. albicans SC5314, or A. fumigatus CGMCC3.7795, or multi-resistant C. albicans 24D[1]
Dosage: 1, 5 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Increased the median survival time (MST) to 6 days at 1.0 mg/kg/day in C. albicans SC5314 challenge.
Increased the MST in a dose-dependent manner significantly in fumigatus CGMCC3.7795 challenge.
Increased the MST to 12 days at 1.0 mg/kg/day in multi-resistant C. albicans 24D challenge.
Animal Model: C. albicans[1].
Dosage: 0.5, 1 mg/kg/day, continue for 5 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced the fungal burden significantly and showed better therapeutic effects than the Luli (HY-14283) (1 mg/kg) group.
Inhibited fungi almost completely in the group at 1.0 mg/kg.
分子量

545.42

Formula

C25H27BrF2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

S-F24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-F242946669-78-7FungalHUVECMCF-10A16HBELO2selectivityinvasive and superficial fungal infection in ICR micefungal infectionInhibitorinhibitorinhibit

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目录号：
HY-149844
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