1. Screening Libraries
  2. Protein Tyrosine Kinase Compound Library

蛋白酪氨酸激酶化合物库 - Protein Tyrosine Kinase Compound Library

Cat. No.: HY-L016
Library Contents: XLSX PDF SDF

蛋白酪氨酸激酶 (PTKs) 是信号通路中的关键分子,也是药物研发中的重要靶点。细胞中存在两类酪氨酸激酶:受体酪氨酸激酶和非受体酪氨酸激酶。受体酪氨酸激酶包括胰岛素受体及多种生长因子受体,如 EGFR、FGFR、VEGFR、NGFR 等。受体酪氨酸激酶是一类跨膜蛋白,可以被相应配体激活,通过磷酸化自身受体 (自磷酸化) 和下游信号蛋白上的酪氨酸残基,将胞外信号传递到细胞质中。PTKs 的主要作用包括调节机体的多细胞功能。有关生长、分化、粘附、运动和死亡的细胞间信号通常通过酪氨酸激酶传递。在人体中,酪氨酸激酶在许多疾病的发生发展中扮演重要角色,包括糖尿病和癌症。

MCE 收录了 537 种酪氨酸激酶信号通路相关的产品,可以用于酪氨酸激酶相关药物筛选及疾病研究。

我们为 MCE 蛋白酪氨酸激酶化合物库 中的所有产品提供溶液包装或粉末包装。溶液包装中,520 个产品以 10 mM 浓度提供,16 个产品以 2 mM 浓度提供,1 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock

Please contact us at

sales@MedChemExpress.cn

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  • Description

  • Product Details

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  • Documentation

Description
& Advantages

•   A unique collection of 537 protein kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as VEGFR, ALK, Btk, Bcr-Abl, c-Met/HGFR, EGFR, FGFR, Insulin Receptor, JAK, PDGFR, etc.

•   A useful tool for the research for PTK-related diseases, such as cancer.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active and cell permeable.

•   Rich documentation with structure, IC50 and summary.

•   NMR and HPLC to ensure the high purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 537 protein kinase inhibitors supplied as pre-dissolved Solutions or Solid
Solution: 520 compounds supplied in 10 mM solution, 16 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Protein Tyrosine Kinase Compound Library

Source: MedChem Express

Contents of Protein Tyrosine Kinase Compound Library
Documentation

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    产品名称:
    Protein Tyrosine Kinase Compound Library
    目录号:
    HY-L016
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    • 96-well Plate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack