1. Screening Libraries
  2. Protein Tyrosine Kinase Compound Library

蛋白酪氨酸激酶化合物库 - Protein Tyrosine Kinase Compound Library

Cat. No.: HY-L016
Library Contents: XLSX PDF SDF

蛋白酪氨酸激酶 (PTKs) 是信号通路中的关键分子,也是药物研发中的重要靶点。细胞中存在两类酪氨酸激酶:受体酪氨酸激酶和非受体酪氨酸激酶。受体酪氨酸激酶包括胰岛素受体及多种生长因子受体,如 EGFR、FGFR、VEGFR、NGFR 等。受体酪氨酸激酶是一类跨膜蛋白,可以被相应配体激活,通过磷酸化自身受体 (自磷酸化) 和下游信号蛋白上的酪氨酸残基,将胞外信号传递到细胞质中。PTKs 的主要作用包括调节机体的多细胞功能。有关生长、分化、粘附、运动和死亡的细胞间信号通常通过酪氨酸激酶传递。在人体中,酪氨酸激酶在许多疾病的发生发展中扮演重要角色,包括糖尿病和癌症。

MCE 收录了 828 种酪氨酸激酶信号通路相关的产品,可以用于酪氨酸激酶相关药物筛选及疾病研究。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 蛋白酪氨酸激酶化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,803 个产品以 10 mM 浓度提供,24 个产品以 2 mM 浓度提供,1 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
规格 (Pre-dissolved Solution or Solid) 价格 是否有货
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

立刻询价 In-stock
50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

立刻询价 In-stock
100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

立刻询价 In-stock
2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

立刻询价 In-stock

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  • 生物活性

  • 产品详情

  • 化合物库组成

  • 产品资料

活性描述 & 特点

•   A unique collection of 828 protein kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as VEGFR, ALK, Btk, Bcr-Abl, c-Met/HGFR, EGFR, FGFR, Insulin Receptor, JAK, PDGFR, etc.

•   A useful tool for the research for PTK-related diseases, such as cancer.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active and cell permeable.

•   Rich documentation with structure, IC50 and summary.

•   NMR and HPLC to ensure the high purity.

•   All compounds are in stock and continuously updated.

产品详情
Formulation:
A collection of 828 protein kinase inhibitors supplied as pre-dissolved Solutions or Solid
Solution: 803 compounds supplied in 10 mM solution, 24 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
化合物库组成

Protein Tyrosine Kinase Compound Library

Source: MedChem Express

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    产品名称:
    Protein Tyrosine Kinase Compound Library
    目录号:
    HY-L016
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack