1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 血管生成化合物库
血管生成化合物库 - Angiogenesis-Related Compound Library

Cat. No.: HY-L088

血管生成是由已有血管生成新的血管的生理过程。血管生成发生在不同的生理过程中,例如胚胎发育、月经周期、运动和伤口愈合等。血管生成受到内源性激活剂及抑制剂的调控,一些主要的内源性激动剂包括 VEGF、bFGF、angiogenin、TGF-β 等,一些主要的内源性抑制剂包括 angiostatin、endostatin、interferon、platelet factor 4 等。血管生成调控失调会引起多种疾病的发生,如癌症、心血管疾病及缺血性疾病等。激活血管生成可以对心血管疾病及缺血性疾病起到一定控制作用,而抑制血管生成可以对癌症发挥一定治疗作用。

MCE 可以提供 1943 种靶向血管生成相关靶点及信号通路的小分子化合物,MCE 血管生成化合物库是进行血管生成相关研究及开发靶向血管生成药物的有效工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 血管生成化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,1905 个产品以 10 mM 浓度提供,35 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1943 small molecule compounds with validated angiogenesis targets modulating properties.

•   Targeting diverse targets, including VEGFR, Ephrin Receptor, PDGFR, FGFR, etc.

•   A useful tool for the research of transcription factor-related regulation and diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 1943 epigenetics related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 1905 compounds supplied in 10 mM solution, 35 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    Inquiry Information

    产品名称:
    Angiogenesis-Related Compound Library
    目录号:
    HY-L088
    需求量: