1. Screening Libraries
  2. Endoplasmic Reticulum Stress Compound Library

内质网应激化合物库 - Endoplasmic Reticulum Stress Compound Library

Cat. No.: HY-L054
Library Contents: XLSX PDF SDF

内质网 (Endoplasmic reticulum, ER) 参与了大约三分之一的细胞蛋白的产生和折叠,对维持细胞内环境稳定及个体健康具有重要的意义。当一些不利因素影响内质网功能及蛋白合成时,会导致内质网应激 (ER stress, ERS) 及未折叠蛋白反应 (UPR) 信号通路激活。当内质网超负荷反应时,UPR 被激活,UPR 反应最初的目标是恢复内质网的稳态和正常的细胞功能,但当这种作用失败时,UPR 反应会诱导内源性细胞凋亡。慢性内质网应激和 UPR 信号缺失正在成为越来越多的人类疾病的关键因素,包括糖尿病、神经退行性变和癌症等,使得 UPR 信号通路成为治疗治疗疾病的潜在靶点。

MCE 内质网应激化合物库收录了 73 个内质网应激相关的化合物,主要靶向 PERK,IRE1 及 ATF6 等内质网应激信号通路中的关键靶点,是研究内质网应激及相关疾病的有用工具。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well (10 mM | 2 mM | 3 mg/mL solution) Get quote In-stock
50 μL/well (10 mM | 2 mM | 3 mg/mL solution) Get quote In-stock
100 μL/well (10 mM | 2 mM | 3 mg/mL solution) Get quote In-stock
2 × 100 μL/well (10 mM | 2 mM | 3 mg/mL solution) Get quote In-stock

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Description
& Advantages

•   A unique collection of 73 ER stress-related small molecules for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as PERK, IRE1, ATF6, etc.

•   A useful tool for drug discovery of ER stress-related diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 73 ER stress compounds supplied as pre-dissolved DMSO solutions or Solid .
Solution: 71 compounds supplied in 10 mM solution, 1 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Container:
96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Endoplasmic Reticulum Stress Compound Library

Source: MedChem Express

Contents of Endoplasmic Reticulum Stress Compound Library
Documentation

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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack