1. Screening Libraries
  2. Anti-Hepatitis C Virus Compound Library

抗丙型肝炎病毒化合物库 - Anti-Hepatitis C Virus Compound Library

Cat. No.: HY-L073
Library Contents: XLSX PDF SDF

丙型肝炎病毒(HCV)是一种包膜、阳性单链 RNA 病毒,属于黄病毒科。HCV 至少分为 6 个基因亚型,其易错聚合酶可产生 50 多个亚型。编码 HCV 多蛋白的长开放阅读框被宿主和病毒蛋白酶处理,生成 3 种结构蛋白(衣壳蛋白核心和包膜糖蛋白 E1 和 E2)和 7 种非结构(NS)蛋白(p7、NS2、NS3、NS4A、NS4B、NS5A 和 NS5B)。

HCV 感染为社会带来重大的公共卫生负担。全球估计有 7100 万人感染了慢性丙肝病毒。相当数量的慢性感染者会发展为肝硬化或肝癌。由于丙型肝炎病毒高突变性,疫苗研制难度较大,还没有开发出有效的 HCV 疫苗。目前,以 HCV 病毒生命周期中关键组分为靶点开发出一些新的治疗方法,包括特异性阻断病毒酶及功能蛋白的直接抗病毒药物及阻断宿主蛋白与病毒相互作用的宿主靶向药物。但是由于 HCV 病毒的高突变性及不同阶段肝病的复杂性,为肝炎的有效治疗带来挑战,目前仍需要不断发现和开发新的 HCV 抑制剂。

MCE 收录了 174 个具有明确及潜在抗 HCV 活性的化合物,是开发新的抗 HCV 药物及抗感染研究的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 抗丙型肝炎病毒化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,172 个产品以 10 mM 浓度提供,2 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock

Please contact us at

sales@MedChemExpress.cn

Top Publications Citing Use of Products
  • Description

  • Product Details

  • Composition

  • Documentation

Description
& Advantages

•   A unique collection of 174 bioactive anti-hepatitis C virus compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets include NS3, NS4A, NS5A, RNA-dependent RNA-polymerases, EGFR, etc.

•   A useful tool for the discovery of anti-HCV drugs.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 174 compounds with anti-HCV activity supplied as pre-dissolved Solutions or Solid
Solution: 172 compounds supplied in 10 mM solution, 2 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Anti-Hepatitis C Virus Compound Library

Source: MedChem Express

Documentation

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

* Container:

       留言给我们:

    Bulk Inquiry

    Inquiry Information

    产品名称:
    Anti-Hepatitis C Virus Compound Library
    目录号:
    HY-L073
    需求量:

    Request SDF File

    Please enter your email address. We will send your requested SDF file to you as soon as possible.

    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack