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  5. E3泛素连接酶配体库
E3泛素连接酶配体库 - E3 Ligase Ligand Library

Cat. No.: HY-L128

蛋白降解靶向嵌合体(PROTAC)已经已成为一种有效的蛋白质靶向降解技术。 PROTACs由E3泛素连接酶配体、连接子和目标蛋白配体(主要是小分子抑制剂)组成。 在与目标蛋白结合后,PROTACs可以招募E3泛素连接酶进行目标蛋白的泛素化,并由蛋白酶体介导降解。

虽然现在已经报道600多种E3泛素连接酶,但只有几种具有小分子配体的E3连接酶用于PROTACs 设计,包括SCF、VHL、CRBN、IAPs及MDM2等。

MCE 精心收集了88种已被报道用于PROTAC设计的E3泛素连接酶配体。MCE E3泛素连接酶配体库是进行PROTAC化合物开发的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE E3泛素连接酶配体库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,88 个产品以 10 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 88 ligands for E3 ligase, which can be used for PROTAC design.

•   A useful tool for PROTAC development.

•   Mainly target VHL, CRBN, IAPs and MDM2.

•   More detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 88 ligands for E3 ligase supplied as pre-dissolved Solutions or Solid.
Solution: 88 compounds supplied in 10 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice

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  •  形式(固体或溶液)
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    E3 Ligase Ligand Library
    目录号:
    HY-L128
    需求量: