1. Screening Libraries
  2. Orally Active Compound Library

口服活性化合物库 - Orally Active Compound Library

Cat. No.: HY-L061
Library Contents: XLSX PDF SDF

口服给药是一种方便且成本低廉的给药方式,是市面上大多数药物的主要给药途径。因此,口服生物利用度(oral bioavailability)是药物设计和开发的关键考虑因素之一。口服生物利用度高的药物在较低的给药剂量下就可以达到预期的药理学效果,因此可以降低药物的毒副作用。相反,口服生物利用度较差的药物可能会影响药效,导致较高的个体间差异性,因此可能会导致药物不可预测的不良反应。临床试验中口服生物利用度低是候选药物未能进入市场的主要原因。

MCE 收录了2136 个明确报道的具有较高口服利用度的化合物,是开发口服活性药物的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 口服活性化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,2096 个产品以 10 mM 浓度提供,37 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock
50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

Get quote In-stock

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sales@MedChemExpress.cn

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Description
& Advantages

•   A unique collection of 2136 compounds with high oral bioavailability for high throughput screening (HTS) and high content screening (HCS).

•   A useful tool for the discovery of drugs with oral bioavailability.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, medicinally active, CNS-penetrant and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 2136 orally active compounds supplied as pre-dissolved Solutions or Solid
Solution: 2096 compounds supplied in 10 mM solution, 37 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Documentation

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    产品名称:
    Orally Active Compound Library
    目录号:
    HY-L061
    需求量:

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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack