1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 根据产品特点分类
  5. 口服活性化合物库
口服活性化合物库 - Orally Active Compound Library

Cat. No.: HY-L061

口服给药是一种方便且成本低廉的给药方式,是市面上大多数药物的主要给药途径。因此,口服生物利用度(oral bioavailability)是药物设计和开发的关键考虑因素之一。口服生物利用度高的药物在较低的给药剂量下就可以达到预期的药理学效果,因此可以降低药物的毒副作用。相反,口服生物利用度较差的药物可能会影响药效,导致较高的个体间差异性,因此可能会导致药物不可预测的不良反应。临床试验中口服生物利用度低是候选药物未能进入市场的主要原因。

MCE 收录了3325 个明确报道的具有较高口服利用度的化合物,是开发口服活性药物的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 口服活性化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,3261 个产品以 10 mM 浓度提供,55 个产品以 2 mM 浓度提供,9 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
- +

Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 3325 compounds with high oral bioavailability for high throughput screening (HTS) and high content screening (HCS).

•   A useful tool for the discovery of drugs with oral bioavailability.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, medicinally active, CNS-penetrant and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 3325 orally active compounds supplied as pre-dissolved Solutions or Solid
Solution: 3261 compounds supplied in 10 mM solution, 55 compounds supplied in 2 mM solution, 9 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

HIV (70)

COX (64)

EGFR (64)

VEGFR (60)

mAChR (46)

CDK (44)

PDGFR (43)

JAK (41)

PI3K (37)

HCV (33)

FGFR (32)

c-Kit (31)

Akt (30)

FLT3 (30)

PPAR (28)

Btk (27)

PARP (26)

iGluR (25)

mTOR (23)

Src (21)

HBV (20)

STAT (20)

nAChR (19)

Raf (19)

CCR (18)

ERK (17)

mGluR (17)

AMPK (16)

HDAC (16)

MMP (16)

Ras (16)

c-Fms (15)

CXCR (15)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

* Container:

       留言给我们:

    Bulk Inquiry

    Inquiry Information

    产品名称:
    Orally Active Compound Library
    目录号:
    HY-L061
    需求量: