2. Apoptosis
  3. Apoptosis
  4. SP94

SP94 是一种对肝细胞癌细胞具有高特异性的肽配体。SP94 在体外选择性的与多种肝细胞癌细胞系结合。SP94 在肝细胞癌小鼠模型中通过促进肿瘤细胞凋亡 (apoptosis) 和减少肿瘤血管生成来抑制肿瘤生长。SP94 可作为特异性探针用于肝细胞癌成像。SP94 可用于肝细胞癌的研究。

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SP94

SP94 Chemical Structure

CAS No. : 1158983-49-3

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SP94 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research[1][2][3].

体外研究
(In Vitro)

SP94 (40 nM HspG41C-SM(PEG)n-SP94，12/23 肽/笼，24 小时) 可以选择性地与 HepG2 和 Huh-7 细胞结合，但不与 HeLa 和 RLN-8 细胞结合[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SP94 相关抗体:

Immunofluorescence[2]

Cell Line: HepG2 and Huh-7 cells
Concentration: 40 nM of HspG41C-SM(PEG)n-SP94, 12/23 peptides/cage
Incubation Time: 24 h
Result: Induced Alexa488 green fluorescence, increased the binding of conjugates with increasing SP94 peptide numbers on liposomes.
体内研究
(In Vivo)

SP94 (100 µg + PC94，一次/1 mg/kg (SP94-LD)，静脉注射，每周一次至两次，连续 2-4 周) 在 Mahlavu 细胞异种移植小鼠模型中可抑制噬菌体颗粒从肿瘤组织中恢复，通过增强肿瘤细胞凋亡并减少的肿瘤血管生成来抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 100 µg + PC94
Administration: once
Result: Inhibited recovery of phage particle from tumor tissue, inhibited 88% of PC94 binding to tumor tissue.
Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 1 mg/kg, with PEGylated liposomal Doxorubicin (HY-15142A) (SP94-LD).
Administration: i.v., twice a week, for 4 consecutive weeks
Result: Reduced the tumor size and weight, with 40% inhibition compared with that in the CP-LD- and LD-treated groups.
Increased the total WBC count, did not change body weight.
Showed marked disseminated necrotic/apoptotic areas, increased apoptotic tumor cells, decreased the density of blood vessels.
Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 5 mg/kg, with PEGylated liposomal Doxorubicin (SP94-LD).
Administration: i.v., once a week, for 2 consecutive weeks
Result: Reduced the tumor size and weight, increased the total WBC count, showed marked disseminated necrotic/apoptotic areas, areas of CD31+ endothelial cells, decreased areas of CD31+ endothelial cells.
分子量

1337.61

Formula

C65H104N14O16
CAS 号
Sequence

Ser-Phe-Ser-Ile-Ile-His-Thr-Pro-Ile-Leu-Pro-Leu
Sequence Shortening

SFSIIHTPILPL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SP94 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP941158983-49-3SP 94SP-94Apoptosispeptide ligandhepatocellular carcinomaHepG2 cellsHuh-7 cellsMahlavu cellssevere combined immunodeficient miceInhibitorinhibitorinhibit

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