Steroid sulfatase/17β-HSD1-IN-5 

Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC₅₀s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research^[1].

IC50: 43 nM (17β-HSD 1)^[1]
IC50: 6.3 μM (17β-HSD 2)^[1]
IC50: 0.4 μM (Steroid sulfatase)^[1]

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (0-40 μM；48-72 小时) 在浓度高达 31 μM (HEK293) 和 23 μM (HepG2)时，对细胞活力没有影响^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) (皮下注射，50 mg/kg，单次给药) 显示 T_1/2 为 3.82 小时，和 C_{max obs} 为 2824 nM^[1]。

Animal Model:	Female C57BL/6 mice (Pharmacokinetic assay)[1]
Dosage:	50 mg/kg
Administration:	Subcutaneous injection (s.c.), single dose
Result:	Pharmacokinetic parameters for Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) in female C57BL/6 mice [1] Route Dose (mg/kg) Cmax obs (nM) C24 (nM) T1/2z (h) AUC0-24 (ng•h/mL) s.c. 50 2824 797 3.82 11600
分子量	430.47
Formula	C21H22N2O6S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (536 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Mohamed Salah, et.al. Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.Journal of Medicinal Chemistry 2023 66 (13), 8975-8992.  [Content Brief]

• [1]. Mohamed Salah, et.al. Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.Journal of Medicinal Chemistry 2023 66 (13), 8975-8992.

Steroid sulfatase/17β-HSD1-IN-5 相关分类

• Metabolic Enzyme/Protease
• Steroid Sulfatase

• 摩尔计算器

• 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
kg g mg μg ng pg	=	M mM μM nM pM	×	L mL μL	×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 (start)	×	体积 (start)	=	浓度 (final)	×	体积 (final)
M mM μM nM pM	×	L mL μL	=	M mM μM nM pM	×	L mL μL
C1		V1		C2		V2

Help & FAQs

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Powered by Bioz See more details on Bioz

Keywords:

Steroid sulfatase/17β-HSD1-IN-5Steroid SulfataseSteroid sulfataseendometriosis17β-HSD117β-HSD2HEK293HepG2Inhibitorinhibitorinhibit

您最近查看的产品: