2. Anti-infection
  3. Bacterial
  4. Sublancin

Sublancin 是一种具有抗菌活性的肽，可抑制 DNA 复制、转录和翻译，而不影响膜的完整性。Sublancin 通过竞争性地结合磷酸转移酶系统 (PTS)，抑制葡萄糖的摄取。Sublancin 抑制菌株 B. subtilis 168 ΔSPβ，MIC 为 0.312 μM。

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Custom Peptide Synthesis

Sublancin Chemical Structure

Sublancin Chemical Structure

CAS No. : 207410-26-2

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Sublancin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sublancin is an antimicrobial peptide, which inhibits DNA replication, transcription and translation, without affecting membrane integrity. Sublancin suppresses glucose uptake for the competition of phosphotransferase system (PTS). Sublancin inhibits B. subtilis strain 168 ΔSPβ with MIC of 0.312 μM[1][2].

体外研究
(In Vitro)

Sublancin (0-500 μM, 24 h) 抑制耐甲氧西林金黄色葡萄球菌 (MRSA)，MIC 为 15 μM，并且在 RAW246.7 巨噬细胞、小鼠腹膜巨噬细胞和人 Caco-2 253 上皮细胞中没有表现出细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sublancin 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW246.7, Caco-2, P-Mac
Concentration: 0-500 μM
Incubation Time: 24 h
Result: Maintained cell viability.
体内研究
(In Vivo)

Sublancin (0.5-4 mg/kg，腹腔注射，单剂量) 通过诱导 IL-6 和 MCP-1，改善 MRSA 感染小鼠模型中的 MRSA 感染，通过抑制 NF-κB 激活减轻肠道炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Methicillin-resistant Staphylococcus aureus infected mice[1]
Dosage: 0.5-4 mg/kg
Administration: ip, single dose
Result: Improved the survival rate, reduced body weight loss.
分子量

3878.38

Formula

C162H254N50O51S5
CAS 号
Unlabeled CAS

Sequence

Gly-Leu-Gly-Lys-Ala-Gln-Cys-Ala-Ala-Leu-Trp-Leu-Gln-Cys-Ala-Ser-Gly-Gly-Thr-Ile-Gly-{Cys(D-glucopyranosyl)}-Gly-Gly-Gly-Ala-Val-Ala-Cys-Gln-Asn-Tyr-Arg-Gln-Phe-Cys-Arg (disulfide bridge: Cys7-Cys36, Cys14-Cys29)
Sequence Shortening

GLGKAQCAALWLQCASGGTIG-{Cys(D-glucopyranosyl)}-GGGAVACQNYRQFCR (disulfide bridge: Cys7-Cys36, Cys14-Cys29)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sublancin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sublancin207410-26-2BacterialInhibitorinhibitorinhibit

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目录号：
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