Sucralose (GMP Like)  (Synonyms: E955 (GMP Like); Trichlorosucrose (GMP Like))

Sucralose (GMP Like) (E955 (GMP Like)) is the GMP Like class Sucralose (HY-N0614) that can be used as pharmaceutical excipients. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents^[1][2].

结果表明，暴露于 2,000 ppm 和 16,000 ppm 浓度的雄性小鼠中，Sucralose 可显著增加所有造血系统肿瘤的发生率，且呈显著的剂量相关性。显微镜下观察，在 2,000 ppm 至 16,000 ppm 浓度的 Sucralose 处理的雄性小鼠中，大多数肿瘤为白血病，累及肺、肝、脾、淋巴结和骨髓，并伴有血管弥漫性浸润和邻近组织广泛浸润^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

397.63

E955 (GMP Like); Trichlorosucrose (GMP Like)

C₁₂H₁₉Cl₃O₈

56038-13-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.  [Content Brief]

  [2]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.  [Content Brief]