1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Tiludronate disodium hemihydrate

Tiludronate disodium hemihydrate (Synonyms: Tiludronic acid disodium hemihydrate)

目录号: HY-A0213B
产品使用指南

Tiludronate (Tiludronic Acid) disodium hemihydrate 是一种口服活性双膦酸盐,可以起到骨调节作用。Tiludronate 用于代谢性骨疾病的研究。Tiludronate disodium hemihydrate 是破骨细胞空泡 H+-ATP 酶的有效抑制剂。

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Tiludronate disodium hemihydrate Chemical Structure

Tiludronate disodium hemihydrate Chemical Structure

CAS No. : 155453-10-4

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Description

Tiludronate (Tiludronic Acid) disodium hemihydrate, an orally active bisphosphonate, can act an osteoregulator. Tiludronate disodium hemihydrate is used for the research of the metabolic bone disorders. Tiludronate disodium hemihydrate is a potent inhibitor of the osteoclast vacuolar H+-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

In Vitro

The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibited proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibited the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

371.57

Formula

C₇H₉ClO₆P₂S.₁/₂H₂O.₂Na

CAS No.

155453-10-4

中文名称

替鲁膦酸二钠半水合物

SMILES

[H]O[H].O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tiludronate disodium hemihydrateTiludronic acid disodium hemihydrateProton PumporalbisphosphonateinflammatoryV-ATPaseosteoporosisyeastInhibitorinhibitorinhibit

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Tiludronate disodium hemihydrate
目录号:
HY-A0213B
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