2. Apoptosis
  3. TNF Receptor
  4. TNF-α-IN-25

TNF-α-IN-25 是一种具有口服活性的 TNF-α 抑制剂。TNF-α-IN-25 在荧光偏振结合实验中的 IC50 为 103 nM，在基于细胞 L929 的实验中 IC50 为 505 nM。TNF-α-IN-25 在葡萄糖-6-磷酸异构酶诱导的关节炎模型中抑制足爪肿胀。TNF-α-IN-25 可用于关节炎研究。

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TNF-α-IN-25

TNF-α-IN-25 Chemical Structure

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TNF-α-IN-25 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNF-α-IN-25 is an orally active TNF-α inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC50 of 103 nM in FP binding assays and L929 assay IC50 of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis[1].

体外研究
(In Vitro)

TNF-α-IN-25 (Compound 10) (< 100 μM, 18 h) 在荧光偏振结合实验中显示 IC50 为 103 nM[1]。
TNF-α-IN-25 (< 50 μM) 在基于细胞 L929 的实验中显示 IC50 为 505 nM[1]。
TNF-α-IN-25 在 HepG2 人细胞中损害线粒体功能，IC50 值大于 40 μM[1]。
TNF-α-IN-25 对 hERG 编码的钾离子通道显示弱至中度抑制，hERG IC50 为 9.2 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNF-α-IN-25 相关抗体:
体内研究
(In Vivo)

TNF-α-IN-25 (Compound 10) (0.1-30 mg/kg，口服，每日两次，持续 17 天) 在葡萄糖-6-磷酸异构酶 (GPI)诱导的关节炎模型中显著抑制足爪肿胀[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/J mice were immunized intradermally at the base of the tail with 100 μL of 1:1 (v/v) emulsion containing 300 μg of glucose-6-phosphate isomerase (GPI) and 200 μg of heat inactivated Mycobacterium tuberculosis H37Ra[1]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o. twice daily for 17 days
Result: Inhibited paw swelling AUC with the 30 mg/kg dose achieving comparable efficacy to anti-TNF antibody treatment.
Inhibited paw swelling AUC dose-dependently.
分子量

416.45

Formula

C23H21FN6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNF-α-IN-25 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-25TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αarthritisInhibitorinhibitorinhibit

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