2. Others Apoptosis
  3. Drug Derivative Apoptosis
  4. TQFL13

TQFL13 是 Thymoquinone (TQ) (HY-D0803) 的衍生物，具有显著的抗乳腺癌活性。TQFL13 对乳腺癌细胞 (BT549, MDA-MB-231, 4T1) 表现出更高的细胞毒性。TQFL13 可促进乳腺癌细胞凋亡 (apoptosis)，并阻滞细胞周期于 S 期和 G2/G1 期。TQFL13 在小鼠乳腺癌同种移植模型中显示出剂量依赖性的抗肿瘤活性。TQFL13 可用于乳腺癌的研究。

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TQFL13

TQFL13 Chemical Structure

CAS No. : 2822560-46-1

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TQFL13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1). TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer[1].

体外研究
(In Vitro)

TQFL13 (0-160 μM, 24 h) 对 BT549、MDA-MB-231、4T1 乳腺癌细胞表现出细胞毒性，对正常 MCF-10A 细胞毒性较低，其 IC50 值分别为 23.80 μM、37.55 μM、17.59 μM 和 >100 μM[1]。
TQFL13 (0-160 μM, 48 h) 对 BT549、MDA-MB-231、4T1 乳腺癌细胞表现出细胞毒性，对正常 MCF-10A 细胞毒性较低，其 IC50 值分别为 12.35 μM、12.14 μM、12.21 μM 和 >100 μM[1]。
TQFL13 (0-20 μM, 24 h) 可增加 4T1 细胞凋亡，并阻滞 BT549 和 MDA-MB-231 乳腺癌细胞的细胞周期于 S 期和 G2/G1 期[1]。
TQFL13 (2.5-5 μM, 0-54 h) 抑制 4T1 细胞的生长、迁移及侵袭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TQFL13 相关抗体:

Apoptosis Analysis[1]

Cell Line: 4 T1 and MDA-MB-231 breast cancer cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Induced the apoptosis.
Reduced the full-length PARP and BCL-2.
Increased the level of BAX.

Cell Cycle Analysis[1]

Cell Line: BT549 and MDA-MB-231 breast cancer cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24 h
Result: Blocked the cell cycle at S and G2/G1 phases.
Downregulated the level of CyclinB1, CyclinD1and p53.
Upregulated the level of phosphorylated p53 (ser15).
体内研究
(In Vivo)

TQFL13 (3.75-15 mg/kg，腹腔注射，自 4T1 细胞接种于乳腺脂垫后第 4 天开始，持续至第 30 天) 在 BALB/c 小鼠乳腺癌异种移植模型中显示抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 mouse breast cancer cells were injected into the fourth mammary fat pads of female BALB/c mice to construct a breast cancer lung metastasis model [1]
Dosage: 3.75, 7.5, 15 mg/kg
Administration: i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30
Result: Showed dose-dependent anti-tumor efficacy.
Showed no significant changes in body weight.
Altered the morphology of breast tumor cells.
Exerted anti-tumor activity by regulating cell apoptosis and cell cycle signaling pathways.
分子量

357.40

Formula

C20H23NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TQFL13 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TQFL132822560-46-1TQFL 13TQFL-13Drug DerivativeApoptosisDrug derivativeBreast cancerThymoquinoneTQ derivativeInhibitorinhibitorinhibit

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