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  4. Trehalose 6,6′-dimycolate

Trehalose 6,6′-dimycolate  (Synonyms: Cord Factor)

目录号: HY-W145657 纯度: ≥97.0%
COA 产品使用指南 技术支持

Trehalose 6,6′-dimycolate (Cord Factor) 是海藻糖 6,6'-二霉酸酯，是结核分枝杆菌的细胞壁糖脂，可用于模拟结核分枝杆菌（MTB）诱导的炎症和肉芽肿形成。Trehalose 6,6′-dimycolate 还保护结核杆菌免受巨噬细胞介导的杀伤，抑制有效的抗原呈递，并减少保护性 T 细胞反应的形成。

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Trehalose 6,6′-dimycolate

Trehalose 6,6′-dimycolate Chemical Structure

CAS No. : 61512-20-7

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Trehalose 6,6′-dimycolate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses[1][2].

体内研究
(In Vivo)

1. 诱导炎症和肉芽肿形成[1]
致病原理
Trehalose 6,6’-dimycolate 阻止钙介导的吞噬体与溶酶体融合，抑制吞噬溶酶体酸化，进而抑制小鼠巨噬细胞对结核分枝杆菌的杀伤作用，并损害机体有效免疫反应，诱导基质金属蛋白酶的表达。
具体造模方法
Mice: C57BL/6 • 雌性 • 6-8 周龄 (持续时间: 7 天)
Administration: 0.5 or 1.25 mg/kg • i.v., 或 先 i.p. 再 i.v. • 单次
造模成功指标
表型观测：巨噬细胞局部聚集，肉芽肿大小和数量增加，炎症加剧，肺泡腔减少，有小的出血点，淋巴细胞主要在肉芽肿与血管交汇处浸润。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (6-8 weeks, 20 g)[1]
Dosage: 0.5, 1.25 mg/kg (10 μg, 25 μg per 20 g mice)
Administration: Intravenous injection (i.v.) once (0.5, 1.25 mg/kg), or received 0.5 mg/kg via Intraperitoneal injection (i.p.) followed by an i.v. after 7 days of 0.5 mg/kg
Result: Increased the lung weight index (LWI). Local aggregation of macrophages was observed 7 days later at 0.5 mg/kg. The size and number of granulomas increased, inflammation intensified, alveolar spaces decreased, small hemorrhagic petechiae appeared, and lymphocytes mainly infiltrated at the intersection of granulomas and blood vessels at 1.25 mg/kg. In i.p.+i.v. model, the inflammatory response was more aggressive. Induced vascular remodeling and collagen deposition.
CAS 号
性状

固体

颜色

White to off-white

中文名称

海藻糖二霉菌酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

COA (279 KB)

产品使用指南 (1538 KB)
参考文献

Trehalose 6,6′-dimycolate 相关分类

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Keywords:

Trehalose 6,6′-dimycolate61512-20-7Cord Factor海藻糖二霉菌酸酯Biochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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