2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Volanesorsen sodium

Volanesorsen sodium  (Synonyms: ISIS 304801 sodium)

目录号: HY-145727A 纯度: 98.51%
COA 产品使用指南 技术支持

Volanesorsen (ISIS 304801) sodium 是一种载脂蛋白CIII (apo-CIII) mRNA 的反义寡核苷酸抑制剂，可以降低甘油三酯水平并改善胰岛素抵抗。Volanesorsen sodium 可用于高甘油三酯血症，家族性乳糜小铁血症综合征和 2 型糖尿病的研究。

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DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), sodium salt

Volanesorsen sodium Chemical Structure

CAS No. : 1573402-50-2

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规格 价格 是否有货 数量
1 mg ￥2300
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5 mg ￥5980
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Other Forms of Volanesorsen sodium:

Volanesorsen sodium 相关抗体

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查看 Apolipoprotein 亚型特异性产品:

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Volanesorsen (ISIS 304801) sodium is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen sodium is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes[1][2][3][4][5].

IC50 & Target[1]

apoC3

 

体内研究
(In Vivo)

Volanesorsen (1.5-50 mg/kg; i.p.; 每周 1 次，连续 2 周) sodium 剂量依赖性地降低了人 apo-CIII 转基因小鼠的人载脂蛋白CIII (apo-CIII) mRNA、血浆 apo-CIII 蛋白和甘油三酯 (TG) 水平[1]。
Volanesorsen (4-40 mg/kg; s.c.; 每周 1 次，连续 13 周) sodium 以剂量反应方式降低了食蟹猴肝脏的 apoC-III mRNA 水平[1]。
Volanesorsen (10 mg/kg; s.c.; 每周 1 次，连续 10 周) sodium 降低了高甘油三酯血症恒河猴的血浆中甘油三酯水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chow-Fed Cynomolgus[1]
Dosage: 4, 8, 12 and 40 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 13 weeks
Result: Reduced apoC-III mRNA by 47%, 51%, 80%, and 89% in a dose-responsive manner.
Animal Model: Rhesus monkeys with hypertriglyceridemia after taking high fructose supplements[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 10 weeks
Result: Reduced plasma triglycerides, very low–density lipoprotein (VLDL)+chylomicron triglyceride, and decreased postprandial triglyceride excursion, while increasing high-density lipoprotein-cholesterol (HDL-C) in hypertriglyceridemic rhesus monkeys.
Clinical Trial
分子量

7165.00

Formula

C230H301N63Na19O125P19S19
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 98.51%

COA (283 KB) LCMS (300 KB)

产品使用指南 (1538 KB)
参考文献

Volanesorsen sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Volanesorsen1573402-50-2ISIS 304801ISIS304801ISIS-304801Apolipoproteinapo-CIIImRNAhypertriglyceridemiafamilial chylosiderosis syndrometype 2 diabetesInhibitorinhibitorinhibit

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