2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. WHN-11

WHN-11 是一种氨基-Artemisinin (HY-B0094) 衍生物，对多种癌细胞系具有抗癌活性。WHN-11 使细胞缺乏 ATP，激活自噬 (autophagy)，并导致细胞凋亡 (apoptosis)。WHN-11 改变了细胞蛋白质稳态途径，诱导线粒体分裂和功能障碍。WHN-11 的抗癌作用与大量活性氧的产生无关。WHN-11 可用于研究三阴性乳腺癌 (TNBC)。

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WHN-11

WHN-11 Chemical Structure

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WHN-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
15 μM
Compound: 9i
Cytotoxicity against human A375 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A375 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
A549 IC50
21.1 μM
Compound: 9i
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
L02 IC50
4 μM
Compound: 9i
Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
MCF7 IC50
2.7 μM
Compound: 9i
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
MDA-MB-231 IC50
5.8 μM
Compound: 9i
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
SH-SY5Y IC50
3.2 μM
Compound: 9i
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
U-87MG ATCC IC50
15.2 μM
Compound: 9i
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29789258]
体外研究
(In Vitro)

WHN-11 对 HCC1937 (IC50 = 0.74 μM)、HCC70 (0.19 μM) 和 MDA-MB-231 三阴性乳腺癌细胞系 (0.5 μM)、HeLa 宫颈癌细胞 (0.84 μM)、U87 胶质母细胞瘤细胞 (6.57 μM)、501mel 黑色素瘤细胞 (0.2 μM) 以及 HCT116 结肠癌细胞系 (0.44 μM) 具有显著的细胞毒性[1]。
WHN-11 可抑制 HCC1937 三阴性乳腺癌细胞系中的肿瘤球形成[1]。
WHN-11 (5-80 μM, 9 days) 以剂量依赖的方式显著减少 HCC1937 细胞的集落形成[1]。
WHN-11 (1-50 μM, 24 h) 以剂量依赖的方式促进 caspase-3 的切割，而非 RARP-1[1]。
WHN-11 不会改变 HCC1937 细胞中 ROS 和 NQO1 mRNA 的水平[1]。
WHN-11 干扰 HCC1937 细胞中的蛋白质稳态，包括泛素化和蛋白酶体降解[1]。
WHN-11 (0.1-40 μM, 1-16 h) 可激活 HCC1937 细胞中的凋亡和自噬信号通路[1]。
WHN-11 (1-50 μM) 导致 HCC1937 细胞存在线粒体应激和功能异常[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WHN-11 相关抗体:

Western Blot Analysis[1]

Cell Line: HCC1937 cells
Concentration: 0.1, 10 and 50 μM
Incubation Time: 1, 4 and 16 h
Result: Induced both autophagy (as indicated by LC3B-I lipidation) and apoptosis (as indicated by caspase-3 cleavage) only after a prolonged exposure of 16 h.
分子量

539.59

Formula

C27H36F3N3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WHN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WHN-11WHN11WHN 11ApoptosisAutophagyAmino-artemisininTriple-negative breast cancerReactive oxygen speciesMitochondrial fissionInhibitorinhibitorinhibit

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