2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. Yhhu-3792 hydrochloride

Yhhu-3792 hydrochloride 是一种 Notch 激活剂。Yhhu-3792 hydrochloride 可增强神经干细胞 (NSC) 的自我更新能力。Yhhu-3792 hydrochloride 可促进 Hes3 和 Hes5 的表达。Yhhu-3792 hydrochloride 可增强小鼠的空间记忆和情景记忆能力。Yhhu-3792 hydrochloride 可用于治疗神经退行性疾病 (例如阿尔茨海默病) 或脑损伤后的神经再生。

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Yhhu-3792 hydrochloride

Yhhu-3792 hydrochloride Chemical Structure

CAS No. : 2624336-93-0

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Yhhu-3792 hydrochloride 的其他形式现货产品:

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Yhhu-3792 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Thhu-3792 can be used for the treatment of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury[1] [2].

体外研究
(In Vitro)

Yhhu-3792 (0.63-2.5 μM, 8 d) hydrochloride 可增加胚胎海马神经干细胞 (NSC) 的数量[1]。
Yhhu-3792 (0.63-2.5 μM, 2 d) hydrochloride 可激活 Notch 信号通路，并促进神经球中 Hes5 和 Hes3 的表达[1]。
Yhhu-3792 (2.5 μM, 7-14 d) hydrochloride 未能显著增加自然杀伤 (NK) 细胞的比例或纯度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Yhhu-3792 hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: Rats neuro-spheres
Concentration: 0.63, 1.25, 2.5 μM
Incubation Time: 2 d
Result: Increased the expression of Notch1 receptor, nuclear NICD, DLL1 and Jagged2.
Significantly increased the expression of Hes5 and Hes3 proteins.

RT-PCR[1]

Cell Line: Rats neuro-spheres
Concentration: 0.63, 1.25, 2.5 μM
Incubation Time: 2 d
Result: Increased the transcription levels of Hes5 and Hes3.
Significantly enhanced the binding of NICD to the promoters of Hes5 and Hes3.
体内研究
(In Vivo)

Yhhu-3792 (10-20 mg/kg, i.p., 每日一次共三周) hydrochloride 可增强海马神经干细胞的自我更新，促进海马神经发生，提高小鼠的空间学习和记忆能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Morris water maze (MWM) assay and fear conditioning (FC) assay established in eight-week-old male C57BL/6 mice[1]
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 weeks
Result: Expanded the NSCs pool and promoted endogenous neurogenesis in the hippocampal dentate gyrus.
Decreased the escape latency of C57BL/6 mice in the MWM test.
increased the freezing time of mice in the Fear conditioning test.
分子量

436.93

Formula

C24H25ClN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Yhhu-3792 hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yhhu-37922624336-93-0Yhhu3792Yhhu 3792NotchNSCsHes3Hes5Dentate gyrusSpatial and episodic memorySelf-renewalInhibitorinhibitorinhibit

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