2. Metabolic Enzyme/Protease Anti-infection
  3. β-glucuronidase Bacterial
  4. β-Glucuronidase-IN-3

β-Glucuronidase-IN-3 (Compound 49) 是一种 β-glucuronidase 共价变构抑制剂。β-Glucuronidase-IN-3 具有强效的大肠杆菌 β-葡萄糖醛酸酶 (EcGUS) 抑制活性 (IC50: 12.9 nM)。β-Glucuronidase-IN-3 通过可逆共价修饰 EcGUS 的半胱氨酸残基 (Cys28、Cys443和Cys197) 发挥抑制作用。β-Glucuronidase-IN-3 能够用于肠道微生物相关疾病的研究，特别是减轻 Irinotecan (HY-16562) 和非甾体抗炎药 (NSAIDs) 的毒性副作用。

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β-Glucuronidase-IN-3 Chemical Structure

β-Glucuronidase-IN-3 Chemical Structure

CAS No. : 3081681-34-4

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β-Glucuronidase-IN-3 相关抗体

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  • 生物活性

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生物活性

β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs)[1].

分子量

264.14

Formula

C10H7N3OSe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Glucuronidase-IN-3 相关分类

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Keywords:

β-Glucuronidase-IN-33081681-34-4β-glucuronidaseBacterialGUSBHCT116 cellsEcGUSintestinal floraCys28Cys443Cys197Inhibitorinhibitorinhibit

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