1. Neuronal Signaling Stem Cell/Wnt
  2. γ-secretase
  3. γ-Secretase modulator 11

5-{8-[(3,4'-二氟[1,1'-联苯]-4-基)甲氧基]-2-甲基咪唑并[1,2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺(1o)表现出较高的体外效力和脑暴露,诱导脑Aβ42水平的显着降低,并表现出对细胞色素p450酶的检测不到的抑制。此外,化合物1o在AD模型小鼠中显示出优异的抗认知缺陷疗效。

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γ-Secretase modulator 11 Chemical Structure

γ-Secretase modulator 11 Chemical Structure

CAS No. : 2434630-29-0

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

5-{8-[(3,4'- difluoro [1,1'- biphenyl]-4-yl) methoxy] - 2-methylimidazo [1,2-a] pyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.

分子量

484.50

Formula

C28H22F2N4O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

γ-Secretase modulator 11 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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γ-Secretase modulator 11
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