1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

目录号: HY-137862 纯度: 99.90%: Data Sheet SDS COA 产品使用指南
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1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) 是一种丰富的溶血磷脂酸种类，由于其对 LPA 受体 (LPA receptors) 的强亲和力，具有很高的生物活性。1-Oleoyl lysophosphatidic acid 在大多数实验室中常用作 LPA 受体激活的试剂。1-Oleoyl lysophosphatidic acid 可增加 SRE 驱动的 β-galactosidase 的活性。

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1-Oleoyl lysophosphatidic acid Chemical Structure

CAS No. : 65528-98-5

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规格	价格	是否有货
mg (22.91 mM * 100 μL in Ethanol)	￥960	In-stock
5 mg (22.91 mM * 500 μL in Ethanol)	￥2500	In-stock
10 mg (22.91 mM * 1 mL in Ethanol)	￥4250	In-stock
25 mg (22.91 mM * 2.5 mL in Ethanol)	现货	询价

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Other Forms of 1-Oleoyl lysophosphatidic acid:

1-Oleoyl lysophosphatidic acid sodium In-stock
(Rac)-1-Oleoyl lysophosphatidic acid 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Neurobiol Stress. 2024 Apr 4:30:100632. [Abstract]

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

生物活性
纯度 & 产品资料
参考文献

生物活性

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation^[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.26 μM Compound: 1, LPA 18:1	Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at mouse LPA4 expressed in CHO cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
HEK293	EC₅₀	18 nM Compound: LPA (18:1)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	29 nM Compound: LPA (18:1)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	IC₅₀	442 nM Compound: LPA	Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate	[PMID: 20536182]
HEK293	EC₅₀	55 nM Compound: LPA (18:1)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	77 nM Compound: LPA (18:1)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	8.1 nM Compound: LPA (18:1)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	970 nM Compound: LPA (18:1)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
MEF	EC₅₀	0.002 μM Compound: 1, LPA 18:1	Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA2 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.35 μM Compound: 1, LPA 18:1	Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA1 expressed in LPA1xLPA2 double knockout mouse MEF cells up to 10 uM by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
MEF	EC₅₀	0.83 μM Compound: 1, LPA 18:1	Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay Agonist activity at human LPA3 expressed in LPA1xLPA2 double knockout mouse MEF cells by Fura-2AM dye based Ca2+ mobilization assay	[PMID: 25100502]
N1E-115	IC₅₀	10 nM Compound: oleoyl-LPA	Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis Displacement of [32P]diazirine-LPA from LPA receptor in mouse N1E-115 cells preincubated for 1 hr in dark followed by UV irradiation for 5 mins by scintillation counting analysis	10.1039/C4MD00333K
RH7777	EC₅₀	0.83 μM Compound: LPA	Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay	[PMID: 31790581]
Sf9	IC₅₀	499.8 nM Compound: 1-O-Oleoyl-LPA	Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis Inhibition of human recombinant autotaxin expressed in insect Sf9 cells using FS-3 as substrate preincubated for 10 mins prior substrate addition measured up to 60 mins by FRET-based analysis	[PMID: 22460025]

体内研究
(In Vivo)

1-Oleoyl lysophosphatidic acid (0.4-2 μg；脑室内；9 周龄雄性 Wistar 大鼠)在陌生条件下在高架十字迷宫 (EPM) 中诱发焦虑样反应^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	9-week-old male Wistar rats^[1]
Dosage:	0.4-2 μg
Administration:	I.c.v.
Result:	Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.

分子量

436.52

Formula

C₂₁H₄₁O₇P

CAS 号

65528-98-5

性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

溶解性数据

细胞实验：

DMSO 中的溶解度 : 10 mg/mL (22.91 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (2.29 mM); 澄清溶液

此方案可获得 ≥ 1 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (2.29 mM); 澄清溶液

此方案可获得 ≥ 1 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 1 mg/mL (2.29 mM); 澄清溶液

此方案可获得 ≥ 1 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.96%

选择批次：

Data Sheet (617 KB) SDS (393 KB)

COA (277 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7. [Content Brief]

[2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452. [Content Brief]

1-Oleoyl lysophosphatidic acid 相关分类

Neurological Disease

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2908 mL	11.4542 mL	22.9085 mL	57.2711 mL
	5 mM	0.4582 mL	2.2908 mL	4.5817 mL	11.4542 mL
	10 mM	0.2291 mL	1.1454 mL	2.2908 mL	5.7271 mL
	15 mM	0.1527 mL	0.7636 mL	1.5272 mL	3.8181 mL
	20 mM	0.1145 mL	0.5727 mL	1.1454 mL	2.8636 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl lysophosphatidic acid65528-98-51-Oleoyl-sn-glycero-3-phosphate 1-Oleoyl-LPALPL ReceptorLysophospholipid ReceptoremotionalbehaviorserumresponsepathologicalanxietydepressionInhibitorinhibitorinhibit

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1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

Customer Review

Other Forms of 1-Oleoyl lysophosphatidic acid:

MCE 顾客使用本产品发表的 1 篇科研文献

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1-Oleoyl lysophosphatidic acid (Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA)

Customer Review

Other Forms of 1-Oleoyl lysophosphatidic acid:

1-Oleoyl lysophosphatidic acid 相关抗体

MCE 顾客使用本产品发表的 1 篇科研文献

1-Oleoyl lysophosphatidic acid 相关产品

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生物活性

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参考文献

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