12S-HHT  (Synonyms: 12(S)-HHTrE)

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂ (PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity^[1][2].

12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells^[2].
12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis^[2].
12S-HHT is an endogenous agonist for BLT2^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

280.40

C₁₇H₂₈O₃

54397-84-1

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36.  [Content Brief]

  [2]. Lee JW, et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44(6):378-386.  [Content Brief]

  [3]. Okuno T, et al. Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021;152:106502.  [Content Brief]