2. Metabolic Enzyme/Protease Apoptosis
  3. Glutathione S-transferase Apoptosis
  4. 2,2′-Dihydroxychalcone

2,2'-DiHydroxychalcone 是一种类黄酮，是一种谷胱甘肽 S-转移酶 (GST) 抑制剂，在人结肠癌细胞中的 IC50 为 28.9 μM。2,2′-Dihydroxychalcone 诱导前列腺癌细胞的细胞周期停滞和细胞凋亡 (apoptosis)。2,2′-Dihydroxychalcone 具有抗癌和抗炎特性。

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2,2′-Dihydroxychalcone Chemical Structure

2,2′-Dihydroxychalcone Chemical Structure

CAS No. : 15131-80-3

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2,2′-Dihydroxychalcone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2].

体外研究
(In Vitro)

2,2′-Dihydroxychalcone （1-50 μM；72 小时）会导致存活率呈剂量依赖性降低，72 小时时 PC3 细胞凋亡随之增加，24 小时治疗时克隆形成存活率降低[ 1]。
2,2′-Dihydroxychalcone （15 μM；6-48 小时）显着降低 Cyclin A 和 Cyclin B1、cdc2 和 PIK1 的蛋白水平[1]。 PC3 cells 1 μM, 5 μM, 15 μM, 25 μM, 50 μM 72 h PC3 cells 15 μM 6 h, 12 h, 24 h, 48 h Induced cell cycle arrest in PC3 cells.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2,2′-Dihydroxychalcone 相关抗体:

Cell Viability Assay[1]

Cell Line: PC3 cells
Concentration: 1 μM, 5 μM, 15 μM, 25 μM, 50 μM
Incubation Time: 72 h
Result: Decreaseed PC3 cell viability and inhibited clonogenic survival.

Apoptosis Analysis[1]

Cell Line: PC3 cells
Concentration: 1 μM, 5 μM, 15 μM, 25 μM, 50 μM
Incubation Time: 72 h
Result: Induced apoptosis in PC3 cells.

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 15 μM
Incubation Time: 6 h, 12 h, 24 h, 48 h
Result: Induced cell cycle arrest in PC3 cells.
分子量

240.25

Formula

C15H12O3
CAS 号
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2,2′-Dihydroxychalcone 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

2,2′-Dihydroxychalcone15131-80-3Glutathione S-transferaseApoptosisGlutathione transferasesGSTsapoptosis inducercell cycle arrestanticancer and anti-inflammatory propertiesflavonoidGSTInhibitorinhibitorinhibit

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