2. Others Cytoskeleton Stem Cell/Wnt
  3. Drug Derivative Cadherin β-catenin
  4. 2,5-Epidithia-3,6-dioxopiperazine

2,5-Epidithia-3,6-dioxopiperazine (Formula 15) 是一种 Epidithiodioxopiperazine (ETP) 衍生物。2,5-Epidithia-3,6-dioxopiperazine 可提高细胞内渗透性，并恢复 2-Cys-Prx (尤其是过氧化物酶 II (PrxII)) 在细胞内模拟的活性。2,5-Epidithia-3,6-dioxopiperazine 可抑制 PDGF 诱导的血管平滑肌细胞增殖和迁移，同时促进 VEGF 诱导的内皮细胞增殖和迁移。2,5-Epidithia-3,6-dioxopiperazine 可有效抑制黑色素瘤细胞的增殖、迁移和肺转移。2,5-Epidithia-3,6-dioxopiperazine 可用于高血压、心绞痛、心肌梗死等血管疾病的研究。

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2,5-Epidithia-3,6-dioxopiperazine

2,5-Epidithia-3,6-dioxopiperazine Chemical Structure

CAS No. : 21056-79-1

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2,5-Epidithia-3,6-dioxopiperazine 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research[1].

分子量

176.22

Formula

C4H4N2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2,5-Epidithia-3,6-dioxopiperazine 相关分类

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Keywords:

2,5-Epidithia-3,6-dioxopiperazine21056-79-1Drug DerivativeCadherinβ-cateninDrug derivativeBeta cateninEpidithiodioxopiperazineETP2-Cys-PrxPrxIIHASMCSHAECSSK-MEL28 cellsVascular diseasesHypertensionAngina pectorisMyocardial infarctionInhibitorinhibitorinhibit

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