1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin  (Synonyms: Anhydroepitetrodotoxin)

目录号: HY-126985 纯度: ≥98.0%
COA 产品使用指南

4,9-Anhydrotetrodotoxin 是一种选择性的电压门控钠通道 (VGSC) 抑制剂,可阻断人脑中的 Nav1.1 和 Nav1.6,并且在失活的 Nav1.6 电压依赖性中诱导超极化偏移。

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4,9-Anhydrotetrodotoxin Chemical Structure

4,9-Anhydrotetrodotoxin Chemical Structure

CAS No. : 13072-89-4

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100 μg ¥8500
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

体外研究
(In Vitro)

4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

301.25

Formula

C11H15N3O7

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

参考文献

4,9-Anhydrotetrodotoxin 相关分类

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产品名称:
4,9-Anhydrotetrodotoxin
目录号:
HY-126985
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