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  3. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 

目录号: HY-135587
产品使用指南

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) 是一种Raloxifene 与叔丁基二甲基甲硅烷基氯的反应产物。4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 可用于合成 Raloxifene 6-glucuronide。

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4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Chemical Structure

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene Chemical Structure

CAS No. : 174264-46-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4) is a reaction product of Raloxifene with tertbutyldimethylsilyl chloride. 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is used to synthesize Raloxifene 6-glucuronide[1].

体外研究
(In Vitro)

The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

587.84

Formula

C34H41NO4SSi

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

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产品名称:
4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene
目录号:
HY-135587
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