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  5. 5'-Methoxynobiletin

5'-Methoxynobiletin 是一种口服有效的镇痛和抗炎剂。5'-Methoxynobiletin 是一种聚甲氧基黄酮类化合物,可以从蒿属植物中分离出来。

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5'-Methoxynobiletin Chemical Structure

5'-Methoxynobiletin Chemical Structure

CAS No. : 6965-36-2

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  • 生物活性

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生物活性

5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides[1][2].

体内研究
(In Vivo)

5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度,并降低几种促炎介质的水平[2]。< br/> 5'-Methoxynobiletin (100 mg/kg,口服,一次) 显示出抗伤害和抗炎活性[2]
5'-Methoxynobiletin (10 mg/kg,静脉注射;50 mg/kg,口服;一次) 在大鼠体内的口服生物利用度较低,约为 8-11%[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (female)[2]
Dosage: 100 mg/kg
Administration: Orally
Result: Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively.
Animal Model: Wistar rats (male)[2]
Dosage: 10 mg/kg (IV), 50 mg/kg (oral)
Administration: IV, oral, once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1].
IV (10 mg/kg) IG (50 mg/kg)
λ (h-1) 0.55±0.03 0.29±0.2
Tmax (h) 2.71±0.49
Cmax (mg/L) 0.62±0.21
AUC0-∞ (mg·h/L) 8.19±4.1 3.65±0.8
t1/2 elimination (h) 1.26±0.1 2.31±0.9
CL (L/h.kg) 1.22±0.26 13.68±0.29
Vd, ss (L/kg) 2.24±0.32 47.46±10.10
F (%) 8.67
分子量

432.42

Formula

C22H24O9

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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产品名称:
5'-Methoxynobiletin
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HY-134602
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