2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 6PGD-IN-2

6PGD-IN-2 是一种非竞争性 6-磷酸葡萄糖酸脱氢酶 (6PGD) 抑制剂，其IC50 值为 5.1 μM。6PGD-IN-2 以底物依赖性方式破坏 6PGD 寡聚化。6PGD-IN-2 诱导 A549 细胞产生 NADPH 和 Ru-5-P 的以及减少 DNA 合成。6PGD-IN-2 可用于非小细胞癌和肝癌的研究。

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6PGD-IN-2

6PGD-IN-2 Chemical Structure

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6PGD-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6PGD-IN-2 is an uncompetitive 6-phosphogluconate dehydrogenase (6PGD) inhibitor with an IC50 of 5.1 μM. 6PGD-IN-2 disrupts 6PGD oligomerization in a substrate-dependent manner. 6PGD-IN-2 results in a decrease of NADPH and Ru-5-P production as well as DNA synthesis in A549 cells. 6PGD-IN-2 can used for the studies of non-small cell carcinoma and liver cancer[1].

体外研究
(In Vitro)

Enpp-1-IN-27 (Compound 19n) (0-300 μM) 对 6PG 和 NADP+ 均表现出非竞争性抑制特性，抑制常数 (Ki) 分别为 64 μM (6PG) 和 9.5 μM (NADP+)[1]。
Enpp-1-IN-27 (0-10 μM, 72 h-14 d) 可抑制 A549 细胞 (抗存活效力，EC50 为 9.0 μM) 和 Huh7 细胞增殖和集落形成[1]。
6PGD-IN-2 (0-40 μM) 可降低 A549 中的 NADPH/NADP+ 比率和 Ru-5-P 水平，减少 DNA 合成[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6PGD-IN-2 相关抗体:
分子量

461.14

Formula

C16H9BrCl2FN3OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6PGD-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6PGD-IN-2DNA/RNA SynthesisA549 cellsHuh7 cellsPentose phosphate pathway (PPP)Metabolic reprogrammingInhibitorinhibitorinhibit

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