2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Apoptosis
  3. Glucocorticoid Receptor Apoptosis
  4. Betamethasone hydrochloride

Betamethasone hydrochloride  (Synonyms: 盐酸倍他米松)

目录号: HY-13570A
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摩尔计算器

Betamethasone hydrochloride 是一种合成糖皮质激素，具有抗炎和免疫抑制活性。Betamethasone hydrochloride 可加速胎儿肺成熟并诱导基因表达和细胞凋亡。

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Betamethasone hydrochloride Chemical Structure

Betamethasone hydrochloride Chemical Structure

CAS No. : 956901-32-9

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Betamethasone hydrochloride 的其他形式现货产品:

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Betamethasone hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone hydrochloride accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].

体外研究
(In Vitro)

Betamethasone (0.1-1 μM; 12 h) induces gene expression in L929 cells[4].
Betamethasone (0.1-1 μM; 48 h) induces CEM C7 T-cells apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betamethasone hydrochloride 相关抗体:
体内研究
(In Vivo)

Betamethasone (0.48 mg; i.v.gtt for 48 h) decreases the hypercapnia-induced increase in CBF due to decreased cerebral vasodilatation[1]. Betamethasone (0.05 ml (1 mg/L); topical injection) ameliorates spinal nerve transection induced mechanical allodynia and thermal hyperalgesia, and reduces the activation of NF-κB and elevation of TNFα and IL-1β, and induces the expression of IL-10 in the rats brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rambouillet-Colombia ewes bred on a single occasion are received hypercapnic challenges[1]
Dosage: 0.48 mg
Administration: Injected into the fetal jugular vein at a rate of 1 ml/h (10 μg betamethasone/h) and maintained over the next 48 h.
Result: Decreased cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 h of infusion.
The reduction in CBF was diminished to about 25-30 % after 48 h of infusion.
Clinical Trial
分子量

428.92

Formula

C22H30ClFO5
CAS 号
中文名称

盐酸倍他米松
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Betamethasone hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Betamethasone956901-32-9盐酸倍他米松Glucocorticoid ReceptorApoptosisglucocorticoidanti-inflammatoryimmunosuppressivefetallungmaturationgeneexpressionapoptosisInhibitorinhibitorinhibit

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