Cholestyramine (Synonyms: 考来烯胺; Cholestyramine resin; Colestyramine)

目录号: HY-104081: Data Sheet SDS COA 产品使用指南
FAQs
技术支持

Cholestyramine (Colestyramine) 是胆汁酸结合树脂，它可以抑制肠胆汁酸吸收导致增加粪便胆汁酸排泄，进而又增加胆固醇胆汁酸合成。

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Cholestyramine Chemical Structure

CAS No. : 11041-12-6

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.

体外研究
(In Vitro)

Cholestyramine (0.1-50 μg/mL) 在暴露 24 小时后产生最显著的结果；与对照细胞相比，流出率为 65%。Cholestyramine 是一种阴离子交换树脂，不溶于水、酒精、氯仿和乙醚。在测定中，Cholestyramine 首先用少量 DMSO 润湿，然后用培养基进一步稀释。用不含 Cholestyramine 的二甲基亚砜 DMSO 制备的空白样品与对照样品没有差异^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Cholestyramine 是一种胆汁酸结合树脂，可抑制肠道胆汁酸吸收，从而导致胆固醇胆汁酸合成增加^[1]。结果表明，与单独使用 Cholestyramine 相比，单独使用 GSPE 和与 Cholestyramine 联合使用对 BA、胆固醇和 TG 代谢的调节不同。值得注意的是，GSPE 降低肠道顶端钠依赖性胆汁酸转运蛋白 (Asbt) 基因表达，而 Cholestyramine 显著诱导表达。与对照组相比，与 GSPE 或Cholestyramine 一起给药可强烈诱导肝脏 BA 生物合成基因表达，尤其是胆固醇 7α-羟化酶 (Cyp7a1)，而联合给药可进一步增强表达。Cholestyramine 治疗会诱导肠道和肝脏胆固醇生成基因表达，而与 GSPE 联合使用会减弱 Cholestyramine 在肝脏中诱导的胆固醇生成增加，但不会减弱肠道中的胆固醇生成增加。Cholestyramine 还会诱导肝脏脂肪生成基因表达，而与 GSPE 联合使用会减弱这种表达^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

CAS 号

11041-12-6

性状

固体

颜色

White to off-white

中文名称

考来烯胺；消胆胺；消胆胺脂；降胆敏

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

1 M HCl 中的溶解度 : < 1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： 0.5% CMC-Na/saline water
Solubility: 60 mg/mL; 悬浊液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

选择批次：

Data Sheet (632 KB) SDS (393 KB)

COA (260 KB) IR (134 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Maugeais C, et al. rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment. Atherosclerosis. 2013 Jul;229(1):94-101. [Content Brief]

[2]. Rebecca M. Heidker, et al. Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver. PLoS One. 2016; 11(4): e0154305. [Content Brief]

[3]. J M Pruckler, et al. Use of a human microvascular endothelial cell line as a model system to evaluate cholesterol uptake. Pathobiology. 1993;61(5-6):283-7. [Content Brief]

Animal Administration ^[2]	Mice are purchased at 7 weeks of age and allowed to acclimate for one week. At 8-weeks of age the mice are given either a control or a 2% Cholestyramine-supplementing diet for 4 weeks (n=18 per group). Body weight for each mouse is recorded weekly. After 4 weeks, the mice in each group are randomly assigned to one of two treatment groups and orally gavaged with either vehicle (water) or GSPE (250 mg/kg) and terminated 14 hours later (n=9 per experimental group). The four treatment groups are as follows: 1. CON: Control diet for 4 weeks following by oral gavage with vehicle (water) for 14 hrs; 2. GSPE: Control diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs; 3.Cholestyramine 2% Cholestyramine-supplementing diet for 4 weeks following by oral gavage with vehicle for 14 hrs; and 4. Cholestyramine+GSPE: 2% cholestyramine-supplementing diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs. Blood is collected from the orbital plexus under isoflurane anesthesia, and intestines and livers are snap-frozen in liquid nitrogen and stored at -80°C until use. At the start of the 14 hr experiment mice are placed into clean cages, and feces are manually collected at the end of the study^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Maugeais C, et al. rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment. Atherosclerosis. 2013 Jul;229(1):94-101. [Content Brief] [2]. Rebecca M. Heidker, et al. Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver. PLoS One. 2016; 11(4): e0154305. [Content Brief] [3]. J M Pruckler, et al. Use of a human microvascular endothelial cell line as a model system to evaluate cholesterol uptake. Pathobiology. 1993;61(5-6):283-7. [Content Brief]

Animal Administration
^[2]

Mice are purchased at 7 weeks of age and allowed to acclimate for one week. At 8-weeks of age the mice are given either a control or a 2% Cholestyramine-supplementing diet for 4 weeks (n=18 per group). Body weight for each mouse is recorded weekly. After 4 weeks, the mice in each group are randomly assigned to one of two treatment groups and orally gavaged with either vehicle (water) or GSPE (250 mg/kg) and terminated 14 hours later (n=9 per experimental group). The four treatment groups are as follows: 1. CON: Control diet for 4 weeks following by oral gavage with vehicle (water) for 14 hrs; 2. GSPE: Control diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs; 3.Cholestyramine 2% Cholestyramine-supplementing diet for 4 weeks following by oral gavage with vehicle for 14 hrs; and 4. Cholestyramine+GSPE: 2% cholestyramine-supplementing diet for 4 weeks following by oral gavage with 250 mg/kg GSPE for 14 hrs. Blood is collected from the orbital plexus under isoflurane anesthesia, and intestines and livers are snap-frozen in liquid nitrogen and stored at -80°C until use. At the start of the 14 hr experiment mice are placed into clean cages, and feces are manually collected at the end of the study^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Maugeais C, et al. rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment. Atherosclerosis. 2013 Jul;229(1):94-101. [Content Brief]

[2]. Rebecca M. Heidker, et al. Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver. PLoS One. 2016; 11(4): e0154305. [Content Brief]

[3]. J M Pruckler, et al. Use of a human microvascular endothelial cell line as a model system to evaluate cholesterol uptake. Pathobiology. 1993;61(5-6):283-7. [Content Brief]

Cholestyramine 相关分类

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholestyramine11041-12-6Cholestyramine resin Colestyramine考来烯胺消胆胺消胆胺脂降胆敏OthersInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cholestyramine (Synonyms: 考来烯胺; Cholestyramine resin; Colestyramine)

Customer Review

MCE 顾客使用本产品发表的 8 篇科研文献