2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. D-Glutamic acid

D-Glutamic acid  (Synonyms: D-谷氨酸; (R)-Glutamic acid)

目录号: HY-100805 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

D-glutamic acid是L-glutamic acid的对映异构体，广泛用于活性分子和食品中。

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D-Glutamic acid Chemical Structure

D-Glutamic acid Chemical Structure

CAS No. : 6893-26-1

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规格 价格 是否有货 数量
500 mg ￥250
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1 g ￥300
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5 g ￥550
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Customer Review

Other Forms of D-Glutamic acid:

D-Glutamic acid 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-Glutamic acid 相关抗体:
体内研究
(In Vivo)

D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

147.13

Formula

C5H9NO4
CAS 号
性状

固体

颜色

White to off-white

中文名称

D-谷氨酸
结构分类
初始来源

Escherichia coli
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

H2O 中的溶解度 : 13 mg/mL (88.36 mM; ultrasonic and adjust pH to 3 with NaOH)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 10 mg/mL (67.97 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥99.0%

COA (189 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[3]

Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

D-Glutamic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7967 mL 33.9836 mL 67.9671 mL 169.9178 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL 33.9836 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL 16.9918 mL
15 mM 0.4531 mL 2.2656 mL 4.5311 mL 11.3279 mL
20 mM 0.3398 mL 1.6992 mL 3.3984 mL 8.4959 mL
25 mM 0.2719 mL 1.3593 mL 2.7187 mL 6.7967 mL
30 mM 0.2266 mL 1.1328 mL 2.2656 mL 5.6639 mL
40 mM 0.1699 mL 0.8496 mL 1.6992 mL 4.2479 mL
50 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3984 mL
60 mM 0.1133 mL 0.5664 mL 1.1328 mL 2.8320 mL
80 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1240 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Glutamic acid6893-26-1(R)-Glutamic acidD-谷氨酸Endogenous MetaboliteInhibitorinhibitorinhibit

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