1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. GW791343 trihydrochloride

GW791343 trihydrochloride 是一种有效的人 P2X7 受体负变构调节剂 (有种属特异性),对人 P2X7 受体产生非竞争性拮抗作用,其 pIC50 值为 6.9-7.2。GW791343 trihydrochloride 能增强昼夜交替的 ATP 释放。GW791343 trihydrochloride 可用于神经系统疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

GW791343 trihydrochloride Chemical Structure

GW791343 trihydrochloride Chemical Structure

CAS No. : 309712-55-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

GW791343 trihydrochloride 的其他形式现货产品:

Other Forms of GW791343 trihydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW791343 trihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 trihydrochloride can enhance ATP rhythm. GW791343 trihydrochloride can be used in study of neurological disease[1][2].

IC50 & Target

P2X7 Receptor

6.9-7.2 (pIC50)

体外研究
(In Vitro)

GW791343 trihydrochloride (0.01, 0.03, 0.1, 0.3, 1, 3, 10 µM; 40 min) shows a non-competitive antagonistic activity to the human P2X7 receptor[1].
GW791343 trihydrochloride (3, 10, 30 µM; 40 min) shows an anegative allosteric modulate activity to the human P2X7 receptor[1].
GW791343 trihydrochloride (5 µM; 24-48 h; ATP measured every 4 h) enhances ATP rhythm in SCN cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HEK293 cells (expressing human recombinant P2X7 receptors).
Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3, 10 µM.
Incubation Time: 40 min (pre-incubate for 10 min and incubate with other P2X7 receptor antagonists for another 30 min).
Result: Inhibited agonist-stimulated ethidium accumulation in both sucrose and NaCl buffer.
Reduced maximal responses toATP and BzATP in sucrose buffer.

Cell Viability Assay[1]

Cell Line: HEK293 cells (expressing human recombinant P2X7 receptors).
Concentration: 3, 10, 30 µM.
Incubation Time: 40 min (pre-incubate for 10 min and incubate with other P2X7 receptor antagonists for another 30 min).
Result: Showed slow reversal effects at the human P2X7 receptor (after 45 min had reversed sufficiently), and had a rapid dissociation rate.

Cell Viability Assay[2]

Cell Line: SCN cells (from 16-to 21- day-old Wistar rats, which are kept under a controlled 12-12 h light-dark cycle from birth).
Concentration: 5 µM (replace the medium with fresh drug-containing culture medium every 4 h).
Incubation Time: 24-48 h (ATP measured every 4 h).
Result: Enhanced the amplitude of ATP release rhythm and extracellular ATP accumulation to 144 of control levels.
分子量

483.81

Formula

C20H27Cl3F2N4O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

GW791343 trihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
GW791343 trihydrochloride
目录号:
HY-15470
需求量: