1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. LAS-31180

LAS-31180 是一种 phosphodiesterase 3 的抑制剂,能够增强肌肉收缩和血管舒张。

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LAS-31180 Chemical Structure

LAS-31180 Chemical Structure

CAS No. : 137338-43-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

体外研究
(In Vitro)

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

252.29

Formula

C11H12N2O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LAS-31180
目录号:
HY-101811
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