2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Idalopirdine

Idalopirdine  (Synonyms: Lu AE58054)

目录号: HY-14338
产品使用指南

摩尔计算器

Idalopirdine (Lu AE58054 ) 是有效，选择性的 5-HT6 受体拮抗剂，Ki 为 0.83 nM。Idalopirdine 可用于阿尔茨海默病和精神分裂症等相关疾病的研究。

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Idalopirdine Chemical Structure

Idalopirdine Chemical Structure

CAS No. : 467459-31-0

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Idalopirdine 的其他形式现货产品:

Other Forms of Idalopirdine:

Idalopirdine 相关抗体

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2].

IC50 & Target

5-HT6 Receptor

0.83 nM (Ki)

体内研究
(In Vivo)

Idalopirdine (intraperitoneal injection, 5 mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models[1].
Idalopirdine (1 or 2 mg/kg, i.v) can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 5 mg/kg
Administration: intraperitoneal injection, daily, 28 days
Result: Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol.
Animal Model: Male Sprague-Dawley rats[2]
Dosage: 1 or 2 mg/kg
Administration: i.v.
Result: No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg.
Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration.
Clinical Trial
分子量

398.37

Formula

C20H19F5N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Idalopirdine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idalopirdine467459-31-0Lu AE58054Lu AE 58054Lu AE-580545-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6 receptorAlzheimer's diseaseschizophreniaInhibitorinhibitorinhibit

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