1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. Soluble epoxide hydrolase inhibitor

Soluble epoxide hydrolase inhibitor 

目录号: HY-U00453
产品使用指南

Soluble epoxide hydrolase inhibitor 是一种可溶性环氧化物水解酶 (soluble epoxide hydrolase (sEH)) 抑制剂,对人 h-sEH 的 pIC50 值为 8.4,摘自专利 WO 2010096722 A1,example 57。

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Soluble epoxide hydrolase inhibitor Chemical Structure

Soluble epoxide hydrolase inhibitor Chemical Structure

CAS No. : 1241826-88-9

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.

IC50 & Target

pIC50: 8.4 (h-sEH)[1]

体外研究
(In Vitro)

Soluble epoxide hydrolase inhibitor (Example 57) is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase with pIC50 of 8.4[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

441.31

Formula

C18H12F5N5O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
Kinase Assay
[1]

The sEH inhibitory properties of test compounds (including Soluble epoxide hydrolase inhibitor) are determined using a black 384-well-plate format under the following reaction conditions: 20 mM Tris pH 7.0, 0.1 mM EDTA, 0.1 mg/mL BSA, 5 μM PHOME (substrate), 2 nM sEH enzyme, 1% DMSO (from test compound). Reaction product is determined quantitatively by fluorescence intensity using a Fluorescence plate reader with an excitation wavelength at 330 nm and emission at 465 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Soluble epoxide hydrolase inhibitor 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Soluble epoxide hydrolase inhibitor
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HY-U00453
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