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  3. TH287 hydrochloride

TH287 hydrochloride 是一种有效的和选择性的 MTH1 抑制剂,IC50 值为 0.8 nM。TH287 hydrochloride 对 MTH1 具有高度选择性,在 100 μM 下对 MTH2,NUDT5,NUDT12,NUDT14,NUDT16,dCTPase,dUTPase 和 ITPA 没有相关抑制作用。TH287 hydrochloride 可以作为癌症治疗的化学研究剂。

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TH287 hydrochloride Chemical Structure

TH287 hydrochloride Chemical Structure

CAS No. : 1638211-05-8

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TH287 hydrochloride 的其他形式现货产品:

Other Forms of TH287 hydrochloride:

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生物活性

TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research[1].

IC50 & Target

IC50: 0.8 nM (MTH1)[1]

体外研究
(In Vitro)

TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

TH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

305.59

Formula

C11H11Cl3N4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

TH287 hydrochloride 相关分类

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TH287 hydrochloride
目录号:
HY-16965A
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