1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. TH588 hydrochloride

TH588 盐酸盐是 MTH1 (NUDT1) 高效选择性抑制剂,IC50 值 5 nM。

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TH588 hydrochloride Chemical Structure

TH588 hydrochloride Chemical Structure

CAS No. : 1640282-30-9

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TH588 hydrochloride 的其他形式现货产品:

Other Forms of TH588 hydrochloride:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).

体外研究
(In Vitro)

TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells
Concentration: 2, 4, 6, 8, 10 μM
Incubation Time: 7–10 days
Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, respectively, but was less toxic to several primary or immortalized cells.
体内研究
(In Vivo)

TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model)[1]
Dosage: 30 mg/kg
Administration: Subcutaneous injection (s.c.); once daily for 35 days
Result: Reduced tumour growth in SW480 xenograft cancer model.
分子量

331.63

Formula

C13H13Cl3N4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

TH588 hydrochloride 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TH588 hydrochloride
目录号:
HY-12814A
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