1. Signaling Pathways
  2. GPCR/G Protein
  3. Adenylate Cyclase

Adenylate Cyclase

cAMP is produced by adenylatecyclase (AC), a 12-transmembrane-spanning enzyme that catalyzes the conversion of ATP to 3′,5′-cAMP and pyrophosphate.

In neuronal and neuroendocrine cells, a variety of ligands, such as neurotransmitters and hormones, signal via activation of G protein coupled receptors (GPCRs) coupled to GSα. These receptors activate adenylatecyclases (ACs), the family of enzymes that generate cAMP.

cAMP is synthesized by adenylatecyclases (ACs) and degraded by phosphodiesterases (PDEs). Local cAMP signaling is achieved by targeting of signaling components to subcellular compartments and assembly of signaling complexes. Primary cilia also host several cAMP-signaling components: the somatostatin 3 receptor (SSTR3), various adenylatecyclases (AC3, AC4, AC6, AC8), PKA, and Epac2 (exchange protein directly activated by cAMP).

Adenylate Cyclase 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-15371
    Forskolin Activator 98.52%
    Forskolin 是一种有效的 腺苷酸环化酶 激活剂,结合到 I 型腺苷酸环化酶 IC50 为 41 nM,激活 I 型腺苷酸环化酶 EC50 为 0.5 μM。
  • HY-100396
    SQ22536 Inhibitor 98.43%
    SQ22536 是一种有效的腺苷酸环化酶 (AC) 抑制剂。
  • HY-P0252
    α-Melanocyte-Stimulating Hormone (MSH), amide Activator 98.55%
    α-Melanocyte-Stimulating Hormone (MSH), amide 刺激黑皮质素1受体,导致腺苷酸环化酶 (adenylyl cyclase) 活化。
  • HY-101279
    ST034307 Inhibitor 98.11%
    ST034307 是一种有效的,选择性的 adenylyl cyclase 1 抑制剂,IC50 值为 2.3 μM。
  • HY-101862
    CB-7921220 Inhibitor >98.0%
    CB-7921220是腺苷酸环化酶 (adenylate cyclase) 的抑制剂。
  • HY-103193
    NKH477 Activator
    NKH477 (Colforsin dapropate hydrochloride) 是一种新型水溶性毛喉素衍生物,主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase) 的催化单元并增加细胞内 cAMP。 NKH477 在体内具有改变的细胞因子谱而发挥抗增殖作用,抑制大鼠原位肺同种异体移植物的急性排斥。
  • HY-P1852
    TIP 39, Tuberoinfundibular Neuropeptide Activator
    TIP 39, Tuberoinfundibular Neuropeptide 是一种神经肽,是甲状旁腺激素 2 受体 (PTH2R) 激动剂。TIP 39 在不同物种中是高度保守的。不同物种中的 TIP 39 都可激活腺苷酸环化酶并通过甲状旁腺激素 2 受体 (PTH2R) 提高细胞内钙水平。
  • HY-100524
    LRE1 Inhibitor
    LRE1是可溶性腺苷酸环化酶的特异性和变构抑制剂。
  • HY-P1495
    Small Cardioactive Peptide B SCPB Activator
    Small Cardioactive Peptide B (SCPB) 是一种神经活性肽,刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性,EC50 分别为 0.1 和 1.0 μM。
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