1. GPCR/G Protein
  2. Adenylate Cyclase
  3. TIP 39, Tuberoinfundibular Neuropeptide

TIP 39, Tuberoinfundibular Neuropeptide 

目录号: HY-P1852
产品使用指南

TIP 39, Tuberoinfundibular Neuropeptide 是一种神经肽,是甲状旁腺激素 2 受体 (PTH2R) 激动剂。TIP 39 在不同物种中是高度保守的。不同物种中的 TIP 39 都可激活腺苷酸环化酶并通过甲状旁腺激素 2 受体 (PTH2R) 提高细胞内钙水平。

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Custom Peptide Synthesis

TIP 39, Tuberoinfundibular Neuropeptide Chemical Structure

TIP 39, Tuberoinfundibular Neuropeptide Chemical Structure

CAS No. : 277302-47-3

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Description

TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R)[1].

Molecular Weight

4504.20

Formula

C₂₀₂H₃₂₅N₆₁O₅₄S

CAS No.

277302-47-3

Sequence

{Ser}{Leu}{Ala}{Leu}{Ala}{Asp}{Asp}{Ala}{Ala}{Phe}{Arg}{Glu}{Arg}{Ala}{Arg}{Leu}{Leu}{Ala}{Ala}{Leu}{Glu}{Arg}{Arg}{His}{Trp}{Leu}{Asn}{Ser}{Tyr}{Met}{His}{Lys}{Leu}{Leu}{Val}{Leu}{Asp}{Ala}{Pro}

Sequence Shortening

SLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
TIP 39, Tuberoinfundibular Neuropeptide
目录号:
HY-P1852
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