1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Chloride Channel

Chloride Channel

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Chloride Channel 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-N0822
    Shikonin Inhibitor 99.80%
    Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂,IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂,还可以抑制 TNF-αNF-κB途径。
  • HY-12693
    R(+)-IAA-94 Inhibitor 99.70%
  • HY-B0679
    Lubiprostone Activator >98.0%
  • HY-101012
    NPPB Inhibitor 99.89%
    NPPB 是外向整流氯化物通道 (ORCC) 的阻断剂。
  • HY-100611
    CaCCinh-A01 Inhibitor 99.60%
    CaCCinh-A01 是 TMEM16A 和钙激活氯化物通道 (CaCC) 的抑制剂,IC50 值分别为 2.1 和 10 μM。
  • HY-P0173B
    Chlorotoxin TFA Inhibitor
    Chlorotoxin TFA 是从蝎子毒液中分离到的多肽,为氯离子通道 (chloride channel) 阻断剂。Chlorotoxin TFA 具有抗癌作用。
  • HY-103368
    Eact Activator
    Eact 是一种选择性强的 TMEM16A 激活剂,直接激活感觉伤害感受器中的 TRPV1 通道,产生瘙痒、急性伤害感受和热敏反应。
  • HY-B1494
    Picrotoxinin Inhibitor
    Picrotoxinin 是一种有效的惊厥药,是一种氯通道 (chloride channel) 阻断剂。Picrotoxinin 是一种非竞争性的 GABAA 受体拮抗剂,负向调节 GABA 对 GABAA受体的作用。
  • HY-B1221
    Flufenamic acid Inhibitor 99.92%
    Flufenamic acid 是一种非甾体类抗炎剂,能够抑制 COX 的活性,激活 AMPK 的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel),调节非选择性阳离子通道,激活钾离子通道 (K+ channel) 等。
  • HY-18996
    Adjudin Inhibitor >98.0%
    Adjudin 是一种广泛研究的男性避孕试剂,具有优越的线粒体抑制作用。 Adjudin 也是一种有效的 Cl- 通道阻断剂。
  • HY-B0493
    Niflumic acid Inhibitor 99.86%
    Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
  • HY-103371
    DCPIB Inhibitor 99.81%
    DCPIB 是一种选择性、可逆、有效的体积调节性阴离子通道 (VRAC) 抑制剂,能够电压依赖性激活钾离子通道 TREK1 和 TRAAK,抑制 TRESK,TASK1 和 TASK3,IC50 值分别为 0.14,0.95,50.72 μM。DCPIB 同时抑制肿胀激活氯电流 (ICl,swell),在 CPAE 细胞中,IC50 值为 4.1 μM。
  • HY-B0908
    Meticrane Inhibitor 98.79%
    Meticrane 是一种利尿剂。Meticrane 抑制远曲小管中钠离子和氯离子的重吸收。Meticrane 可于治疗原发性高血压。
  • HY-105917
    Endovion Inhibitor 99.27%
    Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道),也是特异性的VRAC/VSOAC阻断剂。Endovion (NS3728)还是一种ANO1抑制剂。
  • HY-P0173A
    Chlorotoxin Inhibitor >98.0%
    Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性。Chlorotoxin是氯离子通道 (chloride channel) 阻断剂。
  • HY-100244
    NS1652 Inhibitor
    NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道 (chloride channel),IC50 值为 1.6 μM。
  • HY-100612
    T16Ainh-A01 Inhibitor >99.0%
    T16Ainh-A01 是一类氨基苯基噻唑,是有效的跨膜蛋白 16A 的抑制剂,抑制TMEM16A介导的氯离子电流,IC50 约为1 µM。TMEM16A (ANO1)起钙激活氯离子通道(CaCC)的作用。
  • HY-100322
    H100 Inhibitor
    H100 是一种氯离子运输 (Cl- transport) 抑制剂,可以部分抑制氯离子载体 NaK2Cl cotransporter 和 Band 3 anion exchanger,但是对 KCl cotransporter 无作用。
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