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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR Isoform Specific Products:

  • Estrogen receptor

  • ERα

  • ERβ

  • ERRα

  • ERRβ

  • ERRγ

Estrogen Receptor/ERR 相关产品 (117):

Cat. No. Product Name Effect Purity
  • HY-13757A
    Tamoxifen Modulator 99.95%
    Tamoxifen (ICI 47699) 是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活其他细胞,如骨骼,肝脏和子宫细胞中的雌激素活性。Tamoxifen 是一种有效的 Hsp90 激活剂,可增强 Hsp90 分子伴侣 ATPase 的活性。
  • HY-13636
    Fulvestrant Inhibitor 99.99%
    Fulvestrant (ICI 182780; ZD 9238; ZM 182780) 是有效的雌激素受体 (estrogen receptor) 拮抗剂,IC50值为 9.4 nM。
  • HY-B0141
    Estradiol Agonist 99.99%
    Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。
  • HY-16950
    4-Hydroxytamoxifen Modulator 99.86%
    4-Hydroxytamoxifen是一种选择性的雌激素受体调节剂 (SERM)。
  • HY-13757
    Tamoxifen Citrate Modulator >99.0%
    Tamoxifen Citrate (ICI 46474) 是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活其他细胞,如骨骼,肝脏和子宫细胞中的雌激素活性。Tamoxifen Citrate 是一种有效的 Hsp90 激活剂,可增强 Hsp90 分子伴侣 ATPase 的活性。
  • HY-16950A
    (E/Z)-4-Hydroxytamoxifen Modulator 99.60%
    (E/Z)-4-Hydroxytamoxifen 是 (Z)-4-Hydroxytamoxifen 和 (E)-4-Hydroxytamoxifen 的消旋体。(E/Z)-4-Hydroxytamoxifen 是雌激素受体 (estrogen receptor) 调节剂。
  • HY-128976
    10β,17β-dihydroxyestra-1,4-dien-3-one >98.0%
    10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) 是一种靶向大脑的雌激素 (estrogen) 前体。10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) 是 17β-estradiol 的主要生物前药,可降低脑部温度调节功能障碍的大鼠发生潮热。
  • HY-133017
    SAR439859 Antagonist
    SAR439859 (compound 43d) 是一种具有口服活性,非甾体和选择性雌激素受体降解剂 (SERD)。SAR439859 是一种有效的 ER 拮抗剂,具有 ER 降解活性,EC50 为 0.2 nM。SAR439859 可在 ER+ 乳腺癌中表现出强大的抗肿瘤功效和有限的交叉耐药性。
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 99.81%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD),对 ERα 和 ERβ 的IC50 值分别为 48 和 870 nM。
  • HY-12870
    AZD9496 Antagonist 99.15%
    AZD9496 是有效,选择性的雌激素受体 (ERα) 拮抗剂,IC50 为 0.28 nM。
  • HY-107216
    G-1 Agonist 99.20%
    G-1 是一个非甾体,高亲和力且有选择性的 GPR30 激动剂,其 Ki 值为 11 nM。
  • HY-14590
    Kaempferol Inhibitor 99.62%
    Kaempferol 在乳腺癌细胞中抑制雌激素受体 (estrogen receptor α) 表达,在胶质母细胞瘤细胞和肺癌细胞中,通过激活 MEK-MAPK 诱导细胞凋亡。
  • HY-103456
    PHTPP Antagonist 99.07%
    PHTPP 是一种选择性的 ERβ 拮抗剂。
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.94%
    Raloxifene hydrochloride (LY156758 hydrochloride; LY139481 hydrochloride) 是第二代雌激素受体拮抗剂。
  • HY-N0322
    Cholesterol Agonist >98.0%
    胆固醇 (Cholesterol) 是哺乳动物中主要的甾体类化合物,在基本的细胞生命活动中起到重要作用。
  • HY-A0036
    Bazedoxifene acetate Modulator 99.93%
    Bazedoxifene acetate是第三代选择性雌激素受体调节剂 (SERM)IC50分别为26和99 nM。
  • HY-10426
    XCT790 Antagonist 99.66%
    XCT-790 是 ERRα 的有效选择性反向激动剂,IC50 值为 0.37 μM。XCT-790 在化疗过程中诱导癌细胞死亡。XCT-790 对 ERRγ 和雌激素受体 ERα 和 ERβ 无活性。
  • HY-N2371
    27-Hydroxycholesterol Modulator 99.38%
    27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
  • HY-B1192
    Estradiol benzoate Agonist 99.69%
    Estradiol Benzoate是雌二醇的前体药物,是一种类固醇性激素。Estradiol Benzoate表现出轻微的合成代谢特性,增加血液凝固性。
  • HY-B0234
    Estrone Agonist 99.86%
Isoform Specific Products

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