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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR 相关产品 (100):

Cat. No. Product Name Effect Purity
  • HY-13757A
    Tamoxifen Modulator 99.76%
    Tamoxifen是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活其他细胞,如骨骼,肝脏和子宫细胞中的雌激素活性。
  • HY-13636
    Fulvestrant Inhibitor 99.99%
    Fulvestrant是有效的雌激素受体 (Estrogen Receptor) 拮抗剂,IC50值为 9.4 nM。
  • HY-B0141
    Estradiol Agonist 99.99%
    Estradiol 是一种类固醇性激素,对维持女性的生育能力和第二性征至关重要。
  • HY-16950
    4-Hydroxytamoxifen Modulator 99.86%
    4-Hydroxytamoxifen是一种选择性的雌激素受体调节剂 (SERM)。
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 98.93%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) 是有选择性和口服活性的雌激素受体 (ER)的降解剂,对ERα和ERβ的IC50值分别为48和870 nM。
  • HY-103449
    G15 Antagonist >99.0%
    G15 是一种高亲和力和选择性 G 蛋白偶联雌激素受体 (GPER/GPR30) 拮抗剂,Ki 值为 20 nM。
  • HY-100689
    Propyl pyrazole triol Agonist >99.0%
    Propyl pyrazole triol (PPT) 是一种雌激素受体 α (ERα) 激动剂。Propyl pyrazole triol (PPT) 对 ERα 的相对结合亲和力 (ERα: 49%) 是雌激素受体 β (ERβ: 0.12%) 的 410 倍。
  • HY-111846
    PROTAC ERα Degrader-2 Inhibitor 98.02%
    PROTAC ERα Degrader-2 包含 cIAP1 配体结合基团,linker 和雌激素受体 α (ERα) 配体结合基团。在 MCF7 细胞中,PROTAC ERα Degrader-2 降低 ERα 水平,30 μM 浓度时达到最大降解程度。同时,基于 cIAP1 的降解剂也被称为 SNIPER
  • HY-13757
    Tamoxifen Citrate Inhibitor >99.0%
    Tamoxifen Citrate是一种选择性雌激素受体调节剂 (SERM)。
  • HY-12870
    AZD9496 Antagonist 99.15%
    AZD9496 是有效,选择性的雌激素受体 (ERα) 拮抗剂,IC50 为 0.28 nM。
  • HY-103456
    PHTPP Antagonist 99.07%
    PHTPP 是一种选择性的 ERβ 拮抗剂。
  • HY-N2371
    27-Hydroxycholesterol Modulator 99.38%
    27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
  • HY-10426
    XCT790 Antagonist 98.01%
  • HY-A0036
    Bazedoxifene acetate Modulator 99.93%
    Bazedoxifene acetate是第三代选择性雌激素受体调节剂 (SERM)IC50分别为26和99 nM。
  • HY-107216
    G-1 Agonist 99.20%
    G-1 是一个非甾体,高亲和力且有选择性的 GPR30 激动剂,其 Ki 值为 11 nM。
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.64%
    Raloxifene hydrochloride (LY156758 hydrochloride) 是第二代雌激素受体拮抗剂。
  • HY-14590
    Kaempferol Inhibitor 99.47%
    Kaempferol 在乳腺癌细胞中抑制雌激素受体 (estrogen receptor α) 表达,在胶质母细胞瘤细胞和肺癌细胞中,通过激活 MEK-MAPK 诱导细胞凋亡。
  • HY-B0234
    Estrone Agonist 99.86%
  • HY-12452
    DPN Activator 99.66%
    DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 (ER_beta) 选择性配体。
  • HY-14598
    Diethylstilbestrol Agonist 98.54%
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