2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ZN-c5

ZN-c5 是一种选择性且口服有效的雌激素受体 (estrogen receptor) 降解剂。ZN-c5 在细胞实验中显示出更强的活性 (MCF-7, IC50 = 0.3 nM)，并与 ERα 和 ERβ 具有高亲和力结合 (IC50 分别为 0.4 nM 和 0.8 nM)。ZN-c5 在 MCF-7 小鼠异种移植模型和 WHIM20 异种移植模型中抑制肿瘤生长。ZN-c5 可用于乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ZN-c5

ZN-c5 Chemical Structure

CAS No. : 2136606-87-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ZN-c5 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer[1].

体外研究
(In Vitro)

ZN-c5 (100 nM, 24 h) 在乳腺癌细胞系 (MCF-7、ZR-75-1、CAMA-1、HCC1500 和 HCC1428 细胞) 中诱导 ERα 降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZN-c5 相关抗体:

Western Blot Analysis[1]

Cell Line: MCF-7, ZR-75-1, CAMA-1, HCC1500 and HCC1428 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Induced ERα degradation in breast cancer cell lines.
体内研究
(In Vivo)

ZN-c5 (1-40 mg/kg，口服，每日一次，持续 28 天) 在 MCF-7 小鼠异种移植模型中显示出显著的肿瘤生长抑制作用[1]。
ZN-c5 (40 mg/kg，口服，每日一次，持续 90 天) 在 WHIM20 异种移植模型 (ESR1 突变模型 (Y537S)) 中诱导肿瘤生长抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice were inoculated subcutaneously on the second right mammary fat pad with the single cell suspension of 95% viable tumor cells (1.5 × 107) in 200 μL medium Matrigel mixture (1:1 ratio) without serum[1]
Dosage: 1, 5, 40 mg/kg
Administration: p.o. once daily for 28 days
Result: Resulted in complete tumor growth inhibition at 5 mg/kg.
Animal Model: Female athymic BALB/c nude mice were implanted with a single cell suspension of 1.5 × 106 WHIM20 cells[1]
Dosage: 40 mg/kg
Administration: p.o. once daily for 90 days
Result: Induced tumor growth inhibition and showed no loss in body weight.
分子量

434.48

Formula

C26H24F2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZN-c5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZN-c52136606-87-4Estrogen Receptor/ERRMCF-7WHIM20estrogen receptorbreast cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ZN-c5
目录号：
HY-175260
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z