1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Factor Xa

Factor Xa

Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is an enzyme, a serine endopeptidase, which plays a key role at several stages of the coagulation system. Factor X is synthesized in the liver. Factor Xa has emerged as an attractive target for novel anticoagulants for its key position in the coagulation cascade and its limited roles outside of coagulation. The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. As a result, the past decade has witnessed an explosion of research into small-molecule, oral, direct Factor Xa inhibitors, and several are now in clinical development.

Factor Xa 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-B0597
    Fondaparinux sodium Inhibitor >98.0%
    Fondaparinux sodium 是一种抗凝血酶依赖性的 factor Xa 抑制剂。
  • HY-17567C
    Heparin sodium salt (MW 15kDa) Inhibitor
    Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) 是一种肝素的聚合物,分子量为 15kDa。Heparin sodium salt 是一种抗凝剂,可与抗凝血酶 III (ATIII) 可逆地结合,大大加快了 ATIII 使 thrombin factor IIafactor Xa 失活的速度。
  • HY-B0385
    Gabexate mesylate Inhibitor 98.12%
    Gabexate 甲磺酸盐是非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
  • HY-70035
    Otamixaban Inhibitor 98.97%
  • HY-19373
    RWJ-445167 Inhibitor
    RWJ-445167 (3DP-10017) 是一种有效的 thrombinfactor Xa 双重抑制剂,Ki 值分别为 4.0 nM 和 230 nM,具有抗血栓形成的作用。
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