1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Factor Xa

Factor Xa (凝血因子 Xa)

Factor Xa, a trypsin-like serine protease, is situated at the critical juncture between the intrinsic and extrinsic pathways, catalyzing the conversion of prothrombin to thrombin, and hence plays a pivotal role in the final common pathway of the cascade and has become an important target in the discovery and development of new anticoagulants. Factor Xa is a key protease of the coagulation pathway whose activity is known to be in part modulated by binding to factor Va and sodium ions.

Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots. This cascade is comprised of two arms, the intrinsic and extrinsic pathways which converge at factor Xa to form the common pathway. Factor Xa activates prothrombin to thrombin, which in turn catalyzes the conversion of fibrinogen to fibrin.

Factor Xa 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-B0597
    Fondaparinux sodium Inhibitor ≥98.0%
    Fondaparinux sodium 是一种抗凝血酶依赖性的 factor Xa 抑制剂。
  • HY-17567C
    Heparin sodium salt (MW 15kDa) Inhibitor
    Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) 是一种肝素的聚合物,分子量为 15kDa。Heparin sodium salt 是一种抗凝剂,可与抗凝血酶 III (ATIII) 可逆地结合,大大加快了 ATIII 使 thrombin factor IIafactor Xa 失活的速度。
  • HY-B0385
    Gabexate mesylate Inhibitor 98.12%
    Gabexate 甲磺酸盐是非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
  • HY-70035
    Otamixaban Inhibitor 98.97%
    Otamixaban(FXV673)是高效的fXa选择性可逆型抑制剂,Ki为0.5nM,能抑制游离型或凝血酶原酶结合型fXa。
  • HY-10268S
    Betrixaban D6 Inhibitor
    Betrixaban D6 是 Betrixaban 的氘代化合物。Betrixaban 是一种口服有效的选择性 factor Xa (fXa) 抑制剂。
  • HY-19373
    RWJ-445167 Inhibitor
    RWJ-445167 (3DP-10017) 是一种有效的 thrombinfactor Xa 双重抑制剂,Ki 值分别为 4.0 nM 和 230 nM,具有抗血栓形成的作用。
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