2. Metabolic Enzyme/Protease Anti-infection
  3. Factor Xa Thrombin SARS-CoV
  4. Enoxaparin

Enoxaparin  (Synonyms: PK 10169; Enoxaparin sodium; Lovenox)

目录号: HY-109509
COA 产品使用指南

摩尔计算器

Enoxaparin (PK 10169) 是一种低分子肝素 (LMWH) 衍生物。Enoxaparin 通过抗凝血酶 III 发挥其抗凝血 (anticoagulant) 活性，抗凝血酶 III 是一种内源性 Xa 因子和凝血酶 IIa (thrombin IIa) 的抑制剂。Enoxaparin 可通过抗氧化 (antioxidant) 和抗炎 (anti-inflammatory) 作用保护大鼠海马区免受 TBI 损伤。Enoxaparin 可用于深静脉血栓形成 (DVT)、肺栓塞、外伤性脑损伤 (TBI) 和 COVID-19 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Enoxaparin Chemical Structure

Enoxaparin Chemical Structure

CAS No. : 679809-58-6

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规格 价格 是否有货 数量
1 mg ￥288
In-stock
5 mg ￥720
In-stock
10 mg ￥1150
In-stock
25 mg ￥2200
In-stock
50 mg ￥3400
In-stock
100 mg ￥5250
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Enoxaparin 相关抗体

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Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3].

体外研究
(In Vitro)

Enoxaparin (0-70 µg/mL, 90 min) enhances AAT (alpha-1-antitrypsin) inhibition of both TMPRSS2 (Transmembrane Protease 2) activity and infection of hAEc (human airway epithelial cells) with HCoV-229E[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enoxaparin 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293T TMPRSS2 cells, hAEc
Concentration: 0, 8.8, 35, 70 µg/mL
Incubation Time: 90 min
Result: Significantly inhibited TMPRSS2 activity at the 90 min incubation period at 35 and 70 µg/mL, enhanced AAT inhibition of TMPRSS2 activity, and augmented AAT inhibition of HCoV-229E infection of hAEc.
体内研究
(In Vivo)

Enoxaparin (1 mg/kg; SC; once every 6 h for 8 times) reduces oxidative damage, inflammation and astrocytosis following TBI (traumatic brain injury) in the rat[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (350-450 g, TBI-treated)[2]
Dosage: 0 mg/kg, 1 mg/kg
Administration: SC, once every 6 h, starting at 1 h, and finishing at 43 h after the TBI induction.
Result: Significantly decreased the hippocampal TBARS and oxidized protein levels, COX-2 overexpression and reactive gliosis, but it did not influence the SOD and GSH-Px activities, pro-IL-1β and active caspase-3 overexpressions as well as neurodegeneration following TBI. Reduce oxidative damage, inflammation and astrocytosis following TBI in the rat.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Enoxaparin 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enoxaparin679809-58-6PK 10169 LovenoxPK10169PK-10169Factor XaThrombinSARS-CoVFxaSARS coronavirusLiver fibrosisThioacetamidecoronavirusinfectionCOVID-19traumatic brain injuryneuroprotectiveInflammationblood clotsacute coronary syndromesInhibitorinhibitorinhibit

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