1. Signaling Pathways
  2. GPCR/G Protein
  3. GPCR19

GPCR19 (G蛋白偶联受体19)

GPCR19 (G-protein coupled receptor 19, GPBAR1) is a protein that in humans is encoded by the GPBAR1 gene. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. GPCR19 functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.

GPCR19 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-N0593
    Deoxycholic acid Activator ≥98.0%
    Deoxycholic acid 激活 G 蛋白偶联胆汁酸受体TGR5
  • HY-111534
    SBI-115 Antagonist 99.51%
    SBI-115 是一种 TGR5 (GPCR19) 拮抗剂。SBI-115 通过抑制 TGR5 降低多囊性肝病的肝囊肿形成。
  • HY-B0575
    Triamterene Inhibitor 99.98%
    Triamterene是压敏型上皮钠离子通道(ENaC)阻断剂,有利尿作用。
  • HY-N0593A
    Deoxycholic acid sodium salt Activator ≥98.0%
    Deoxycholic acid sodium salt 激活 G 蛋白偶联胆汁酸受体TGR5
  • HY-14229
    TGR5 Receptor Agonist Agonist 99.85%
    TGR5 Receptor Agonist (CCDC) 是 TGR5(GPCR19) 激动剂。
  • HY-N0169
    Hyodeoxycholic acid Agonist ≥99.0%
    Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸,为 TGR5 (GPCR19) 的激动剂,在 CHO 细胞中,EC50 值为 31.6 µM。
  • HY-102016
    SB756050 Agonist 99.32%
    SB756050 是选择性的 TGR5 激动剂。SB756050有潜力用于二型糖尿病的研究。
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