1. GPCR/G Protein Metabolic Enzyme/Protease
  2. G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite
  3. Sodium taurodeoxycholate hydrate

Sodium taurodeoxycholate hydrate  (Synonyms: 牛磺脱氧胆酸钠水合物)

目录号: HY-W089835 纯度: ≥97.0%
COA 产品使用指南

Sodium taurodeoxycholate hydrate 是一种胆汁酸,是由肝脏中的胆固醇合成的两亲性表面活性剂分子。 除 TGR5 通路外,Sodium taurodeoxycholate hydrate 还激活 S1PR2 通路。

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Sodium taurodeoxycholate hydrate Chemical Structure

Sodium taurodeoxycholate hydrate Chemical Structure

CAS No. : 207737-97-1

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway[1].

IC50 & Target

Microbial Metabolite

 

体外研究
(In Vitro)

The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals[1].
Taurodeoxycholate inhibits the binding of N-3H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC50 of 170 µM[1].
Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation[2].
Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: IEC-6 and caco-2 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 1, 2, 4 and 6 days
Result: Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[2]

Cell Line: IEC-6 cells
Concentration: 0, 0.05, 0.50, and 1.00 mM
Incubation Time: 24 h
Result: Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis[2]

Cell Line: IEC-6 cells
Concentration: 0.5 mM
Incubation Time: 1 and 6 days
Result: Significantly increased c-myc protein expression.
体内研究
(In Vivo)

Taurodeoxycholate (0.5 mg/kg; i.v.; once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis[1]
Dosage: 0.5 mg/kg
Administration: Intravenous injection, 30 min or 24 h after LPS injection
Result: Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.
分子量

521.69

Formula

C26H44NNaO6S

CAS 号
性状

固体

颜色

White to off-white

中文名称

牛磺脱氧胆酸钠水合物

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶)

DMSO 中的溶解度 : 100 mg/mL (191.68 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9168 mL 9.5842 mL 19.1685 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥97.0%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9168 mL 9.5842 mL 19.1685 mL 47.9212 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL 9.5842 mL
10 mM 0.1917 mL 0.9584 mL 1.9168 mL 4.7921 mL
15 mM 0.1278 mL 0.6389 mL 1.2779 mL 3.1947 mL
20 mM 0.0958 mL 0.4792 mL 0.9584 mL 2.3961 mL
25 mM 0.0767 mL 0.3834 mL 0.7667 mL 1.9168 mL
30 mM 0.0639 mL 0.3195 mL 0.6389 mL 1.5974 mL
40 mM 0.0479 mL 0.2396 mL 0.4792 mL 1.1980 mL
50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.9584 mL
60 mM 0.0319 mL 0.1597 mL 0.3195 mL 0.7987 mL
80 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5990 mL
100 mM 0.0192 mL 0.0958 mL 0.1917 mL 0.4792 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sodium taurodeoxycholate hydrate
目录号:
HY-W089835
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