1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Hippo (MST)

Hippo (MST) 

Hippo signaling pathway, also known as the Salvador/Warts/Hippo (SWH) pathway, controls organ size in animals through the regulation of cell proliferationand apoptosis. The Hippo pathway consists of a core kinase cascade in which Hpo phosphorylates the protein kinase Warts (Wts) Hpo (MST1/2 in mammals) is a member of the Ste-20 family of protein kinases. This highly conserved group of serine/threonine kinases regulates several cellular processes, including cell proliferation, apoptosis, and various stress responses.

Hippo (MST) 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-100526
    XMU-MP-1 Inhibitor 99.71%
    XMU-MP-1是可逆和选择性的 MST1/2 抑制剂,IC50 分别为71.1和38.1 nM。
  • HY-101275
    EMT inhibitor-1 Inhibitor 99.27%
    EMT inhibitor-1 是 HippoTGF-βWnt 信号通路的抑制剂,并拥有抗肿瘤活性。
  • HY-128206
    I3MT-3 Inhibitor 99.90%
    I3MT-3 (HMPSNE) 是有效、选择性和具有细胞膜渗透性的 3-巯基丙酮酸硫转移酶 (3MST) (IC50=2.7 μM) 的抑制剂,对其他硫化氢/磺胺制硫酶没有活性。I3MT-3 靶向位于 3MST 活性位点的过硫半胱氨酸残基。
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